Method for producing self-reproducing mammalian pancreatic islet

Details Method for producing self-reproducing mammalian pancreatic islet Method for producing self-reproducing mammalian pancreatic islet

1981-10-21

1984-03-27

Rosen, Sam

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

435240, 435241, A01N 102, C12N 500, C12N 502

Patent

active

044395213

ABSTRACT:
Method for producing pancreatic islet-like structures (ILS's) having histology and insulin-producing properties corresponding to those of fetal pancreatic islets and islets from adult animals maintained in culture. The ILS's are produced by culturing isolated natural pancreatic islets, pancreatic duct pieces, cell clusters consisting of mildly digested pieces of pancreas, cell tissues obtained as by-products of the culturing methods, or previously-produced ILS's, in attachment to a substrate.

REFERENCES:
patent: 4332893 (1982-06-01), Rosenberg
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Okeda et al.-Chem. Abst., vol. 94 (1981), p. 28,004u.
Dudek R. W. et al., "Morphological Study of Cultured Pancreatic Fetal Islets . . . " Diabetes, vol. 29, Jan. 1980, pp. 16-21.
Hellerstrom C. et al., "Method for the Large-Scale Isolation of Pancreatic Islets . . . " Diabetes, vol. 28, Aug. 1979, pp. 769-776.
Nielsen J. W. et al., "Preservation of Beta Cell Function . . . " Diabetologia, 16, pp. 97-100 (1979).
Tze W. J. et al., "Long-Term Survival of Adult Rat Islets of Langerhans . . . ", Diabetes, vol. 26, No. 3, pp. 185-191, Mar. 1979.
Goldman H. et al., "Human Pancreatic Islets in Culture: Effects of . . . " Science June, 1976, pp. 1014-1016.
Takaki R. et al., "Long-Term Culture of Isolated Pancreatic Islet Cells", Proc. Soc. for Experimental Biology and Medicine 149, 402-406 (1975).
Hilwig I. et al., "Uber dars Wachstrum de Pankreaszellen von Saugetieren als Monolayer Cultures", Z. Zellforsch 103, 282-290 (1970).

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