Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alk

Details Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alk Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alk

1997-12-10

1999-06-01

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558342, C07C25510, C07C25312

Patent

active

059089539

ABSTRACT:
Crude (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester, obtained by subjecting an (S)-4-halogeno-3-hydroxybutyric acid lower alkyl ester to a cyano-introducing reaction, is purified by distillation carried out in the presence of a solvent having a boiling point within the range of 50.degree. C. to 160.degree. C. at 10 Torr.

REFERENCES:
patent: 4895979 (1990-01-01), Noyori et al.
patent: 5155251 (1992-10-01), Butler et al.
patent: 5430171 (1995-07-01), Mitsuhashi et al.
Bock, K., et al, "Synthesis of S-and R-4-amino-3-hydroxybutyric Acid (GABOB) and S-and-R-Carnitine from Arabinose or Ascorbic acid," Acta Chemica Scandinavica B 37 (1983): 341-344.
Isbell, H., et al. "Oxidation of L-ascorbic acid by hydrogen peroxide: preparation of L-threonic acid," Carbohydrate Research, 72 (1979) 301-304.
Lespieau, R., "Nitriles .beta.-oxyglutarique, .beta.-bromoglutarique et gultaconique," Bull Fr. Chem, 33 (1923): 725-733.

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