Method for producing pyrimidine

Details Method for producing pyrimidine Method for producing pyrimidine

1973-05-10

1976-05-04

Brust, Joseph P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260463, 260465D, 2604654, C07D23900

Patent

active

039547566

ABSTRACT:
2-Alkyl-4-amino-5-formylaminomethylpyrimidine is produced in a higher yield and using less process steps than the known methods by subjecting .beta.-aminopropionitrile to formylation in the presence of metal alcoholate, subjecting the resulting metal salt of .alpha.-formyl-.beta.-formylaminopropionitrile to alkylation or acylation, followed by allowing the thus produced .alpha.-alkoxy (or acyloxy)-methylene-.beta.-formylaminopropionitrile to react with an amidine.

REFERENCES:
patent: 2602794 (1952-07-01), Hitchings et al.
patent: 2658897 (1953-11-01), Hitchings et al.
patent: 2820050 (1958-01-01), Hultquist
patent: 3036075 (1962-05-01), Kaiser
patent: 3211778 (1965-10-01), Kollonitsch
patent: 3830812 (1974-08-01), Ramsey
Brown, "Heterocyclic Compounds-The Pyrimidines," 1962, pp. 61-62.

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