Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1995-06-07
1998-01-13
Degen, Nancy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530412, 530413, C07K 14285
Patent
active
057081492
ABSTRACT:
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
REFERENCES:
patent: 5141743 (1992-08-01), Schryvers
Ferron, et al 1993. FEMO Microbiol. Letters 109: 159-166.
Schryvers, 1989. J. Med. Microbiol. 29: 121-130.
Sofer, et al. 1983. BioTechniques, "Designing an Optimal Chromatographic Purification Scheme for Proteins".
Stevenson, et al. 1992. Infect. and Immun. 60(6):2391-96.
Cornelissen, et al. 1992. J. Bact. 174(18): 5788-97.
Chong Pele
Gray-Owen Scott
Harkness Robin
Klein Michel
Loosmore Sheena
Connaught Laboratories Limited
Degen Nancy
Latimer Matthew
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