Method for producing protein microspheres

Details Method for producing protein microspheres Method for producing protein microspheres

1992-06-23

1993-12-21

Stoll, Robert L.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

4272133, 42721336, 424491, 424499, 426 96, B01J 1312, A61K 916, A61K 952, A61K 954

Patent

active

052719618

ABSTRACT:
Protein microspheres are formed by phase separation in a non-solvent followed by solvent removal. The preferred proteins are prolamines, such as zein, that are hydrophobic, biodegradable, and can be modified proteolytically or chemically to endow them with desirable properties, such as a selected degradation rate. Composite microspheres can be prepared from a mixture of proteins or a mixture of proteins with one or more bioerodible polymeric materials, such as polylactides. Protein coatings can also be made. Compounds are readily incorporated into the microspheres for subsequent release. The process does not involve agents which degrade most labile proteins. The microspheres have a range of sizes and multiple applications, including drug delivery and delayed release of pesticides, fertilizers, and agents for environmental cleanup. Selection of microsphere size in the range of less than five microns and mode of administration can be used to target the microparticles to the cells of the reticuloendothelial system, or to the mucosal membranes of the mouth or gastrointestinal tract. Larger implants formed from the microspheres can also be utilized, especially for agricultural applications.

REFERENCES:
patent: 3092553 (1963-06-01), Fisher, Jr. et al.
patent: 3116206 (1963-12-01), Brynko et al.
patent: 3937668 (1976-02-01), Zolle
patent: 3943063 (1976-03-01), Morishita et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4194013 (1980-03-01), Rehacek et al.
patent: 4420442 (1983-12-01), Sands
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 4876094 (1989-10-01), Benton
patent: 4940588 (1990-08-01), Sparks et al.
patent: 4952402 (1990-08-01), Sparks et al.
patent: 5021248 (1991-06-01), Stark et al.
Sato et al., Pharmaceutical Research, vol. 5, No. 1, "Porous Biodegradable Microspheres . . . " (1988).
Tice, et al., J. Controlled Rel. 2, 343-352 (1985).
Suzuki, et al., Pharm. Soc. Jap. Chem. Pharm. Bull. 37 (4), 1051-1054 (1989).

Affiliated with

Also associated with

Rating

Method for producing protein microspheres does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing protein microspheres, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing protein microspheres will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-307645