Method for producing protein containing nonprotein amino acids

Details Method for producing protein containing nonprotein amino acids Method for producing protein containing nonprotein amino acids

1988-04-25

1989-11-07

Rosenberg, Peter D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

C12P 2100

Patent

active

048792233

ABSTRACT:
A protein having nonprotein amino acids can be produced by a method which comprises providing a protein-producing organism with a nutrient containing nonprotein amino acids, cells being cultured to produce the protein in a medium containing the nonprotein amino acids, in which method expression of a gene coding for the protein is induced under conditions in which normal cell growth is suppressed.

REFERENCES:
patent: 2180637 (1939-11-01), Kemmerer
patent: 4119493 (1978-10-01), Isowa
patent: 4568640 (1986-02-01), Rubin
Brown & Otros, "4-Fluorotryptophan Alkaline Phosphatase From E. coli," Biochemical & Biophysical Research Communications, vol. 68, No. 3, pp. 907-913 (1976).
Hagen, Weiner and Sykes, "Fluorotyrosine M13 Coat Protein," Biochemistry, vol. 17, No. 18, pp. 3860-3866 (1978).
Sykes, Weingarten & Schlesinger "Fluorotyrosine Alkaline Phosphatase from Escherichia coli," Proc. Nat., Acad. Sci., vol. 71, No. 2, pp. 469-473 (1974).
Wilson Hatfield, "Incorporation of Modified Amino Acids into Proteins In Vivo", Biochimica et Biophysica Acta, vol. 781, pp. 205-215 (1984).

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