Method for producing polyglutamic acid or a salt thereof

Details Method for producing polyglutamic acid or a salt thereof Method for producing polyglutamic acid or a salt thereof

1990-07-23

1993-12-07

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 711, 435836, 435839, C12P 2104, C12R 110, C12R 112

Patent

active

052682790

ABSTRACT:
In a fermentive production of polyglutamic acid and a salt thereof, the accumulation of polyglutamic acid can be markedly increased in a very simple manner by adding an alkaline earth metal ion to the medium in a concentration of not less than 0.05 mole per liter.

REFERENCES:
Chemical Abstracts, vol. 63, 1965, p. 3339, "IV. Chemical constituents of mucilage in natto. 2."
Chemical Abstracts, vol. 68, 1968, p. 58521r, "Polyglutamic acid fermentation."
Sawao Murao, "Polyglutamic acid fermentation" Kobunshi, 16(188), pp. 1204-1212 (1967).
Hisao Fujii, "Formation of mucilage by Bacillus natto. N. Chemical constituents of mucilage in natto. 2." Nippon Nogei Kagaku Kaishi (Jnl. of Agric. Chem. Soc. of Japan) 37(8), pp. 474-477 (1963).
C. Gomez Leonard et al., "Effects of Some Metallic Ions on Glutamy Polypeptide Synthesis by Bacillus Subtilis" Journal of Bacteriology, vol. 76, pp. 499-503 (1958).
R. M. Ward et al., "Polyglutamic Acid Production by Bacillus subtilis NRRL B-612 Growth on Wheat Gluten", Biotechnology and Bioengineering, vol. V, pp. 41-48 (1963).

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