Method for producing oriented connective tissue

Details Method for producing oriented connective tissue Method for producing oriented connective tissue

1995-06-07

1998-05-26

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435177, 435182, 435383, 435395, 623 1, C12N 500

Patent

active

057563500

ABSTRACT:
The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent.

REFERENCES:
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patent: 4485096 (1984-11-01), Bell
patent: 4485097 (1984-11-01), Bell
patent: 4539716 (1985-09-01), Bell
patent: 4546500 (1985-10-01), Bell
Bell, E., et al., "Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro", PNAS USA, 76(3):1274-1278 (1979).
Weinberg, C.G. and Bell, E., "Regulation of Proliferation of Bovine Aortic Endothelial Cells, Smooth Muscle Cells, and Adventital Fibroblasts in Collagen Lattices", J. Cell Physiol., 122:410-414 (1985).
Ehrlich, H.P., "Contraction of Collagen Lattice By Peritubular Cells From Rat Testis", J. Cell Sci., 82:281-294 (1986).
Weinberg, C.B. and Bell, E., "A Blood Vessel Model Constructed From Collagen and Cultured Vascular Cells", Science, 231:397-400 (1986).
Aggarwal, A., A Syngeneic Ligament Equivalent, Phase I: Mechanical... Lattice, B.S., Thesis M.I.T.
Yates, B.A., Development of Vascular Substitute From Living Tissue-Equivalent: Initial Stage, B.S., Thesis M.I.T., Catalogued Oct. 31, 1985.

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