Method for producing optically active phenylpropionic acid deriv

Details Method for producing optically active phenylpropionic acid deriv Method for producing optically active phenylpropionic acid deriv

1999-02-16

2000-02-29

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

560 39, 560 41, 560 12, C07C32720

Patent

active

060311215

ABSTRACT:
Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-hydroxymethyl-3-phenylpropionic acid and glycine benzyl ester to condensation to subsequently convert the hydroxyl group into an elimination group, and substituting the elimination group with an acetylthio group.

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