Method for producing optically active endo-2-norborneols

Details Method for producing optically active endo-2-norborneols Method for producing optically active endo-2-norborneols

1995-08-22

1997-02-18

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435155, 435197, 435198, 435280, C12P 762, C12P 702

Patent

active

056041209

ABSTRACT:
The present invention provides a method for producing optically active endo-2-norborneols, represented by the following formula: ##STR1## and the antipodes, it comprises asymmetrically hydrolysing racemic endo-2-acyloxynorbornane or endo-2-acyloxynorbornane, whose (R)-compound is in excess, having an optical purity of 50-95% ee with lipase derived from Candida genus. The optically active endo-2-norborneol useful for synthesizing intermediates of pharmaceutical preparations in large quantities.

REFERENCES:
patent: 5270206 (1993-12-01), Saccomano
patent: 5407828 (1995-04-01), Kierkels et al.
patent: 5459067 (1995-10-01), Kageyama et al.
Brackenridge et al. J Chem Soc. Perkin Trans 1 (1993) 1093-1094 "Enzymatic Resolution of Oxalate Esters of a Tertiary Alchol Using Porcing Pancreatic Lipase".

Affiliated with

Also associated with

Rating

Method for producing optically active endo-2-norborneols does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing optically active endo-2-norborneols, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing optically active endo-2-norborneols will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1601972