Method for producing optically active amino alcohols

Details Method for producing optically active amino alcohols Method for producing optically active amino alcohols

2000-07-25

2001-10-30

Geist, Gary (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C568S885000, C564S355000

Reexamination Certificate

active

06310254

ABSTRACT:

The present invention relates to an improved process for preparing optically active amino alcohols by reduction of corresponding amino acids using ruthenium catalysts.
A process for preparing optically active amino alcohols by catalytic hydrogenation of the corresponding amino acids over ruthenium catalysts is described in EP-A 696 575. The enantiomeric excesses of the amino alcohols prepared in this way do not yet meet the high demands made of precursors for pharmaceuticals and crop protection agents. In addition, the achievable yields and the reaction times required in the process of EP-A 696 575 are not particularly favourable.
There is therefore a need for a process for preparing optically active amino alcohols having an enantiomeric excess of over 99% which can be carried out readily, simply and inexpensively.
We have now found a process for preparing optically active amino alcohols from optically active amino acids by reduction with hydrogen in the presence of ruthenium-containing catalysts, which is characterized in that the reduction is carried out with addition of acids.
The process of the invention can be carried out using, for example, optically active amino acids of the formula (I)
where
R represents straight-chain or branched C
1
-C
12
-alkyl, C
7
-C
12
-aralkyl or C
6
-C
10
-aryl, which may each be substituted by NR
3
R
4
, OH or COOH,
R
1
, R
2
, R
3
and R
4
each represent, independently of one another, hydrogen, straight-chain or branched C
1
-C
12
-alkyl or C
3
-C
8
-cycloalkyl, where
R
1
and R
2
and also R
3
and R
4
may in each case, independently of one another, together also represent —(CH
2
)
m
—, where m=an integer from 4 to 7, and
where R and R
1
may together also represent —(CH
2
)
o
—, where o=an integer from 2 to 6, and
n represents zero or an integer from 1 to 5,
to give optically active amino alcohols of the formula (II)
where
R, R
1
, R
2
and n are as defined for formula (I).
In the formulae (I) and (II), R preferably represents straight-chain or branched C
1
-C
4
-alkyl which may be substituted by NR
3
R
4
, OH or COOH or represents benzyl. R
1
, R
2
, R
3
and R
4
preferably each represent, independently of one another, hydrogen or straight-chain or branched C
1
-C
4
-alkyl, where R
1
and R
2
and also R
3
and R
4
may in each case, independently of one another, together also represent —(CH
2
)
m
—, where m=4 or 5, and where R and R
1
may together also represent —(CH
2
)
o
—, where o=3 or 4. n preferably represents 0, 1 or 2.
In addition, preference is given to R
1
and R
2
being identical or together representing a polymethylene bridge. The same applies to R
3
and R
4
.
Particularly preferred amino acids of the formula (I) are alanine, valine, leucine, isoleucine, threonine, ornithine, aspartic acid, glutamic acid, phenylalanine and proline.
The process of the invention can be carried out, for example, with addition of from 0.5 to 1.5 equivalents of an organic or inorganic acid per 1 equivalent of basic groups in the optically active amino acid used. As acids, preference is given to inorganic acids, in particular sulphuric acid, hydrochloric acid and phosphoric acid. The acids can, for example, be used as such, in the form of aqueous solutions or in the form of their separately prepared adducts with the amino acids used, e.g. as sulphates, hydrogensulphates, hydrochlorides, phosphates, dihydrogenphosphates or monohydrogenphosphates.
The amount of acid to be added is preferably selected so that after its addition all carboxyl groups in the amino acid used are present in protonated form. Preference is given to using from 1 to 1.3 equivalents of organic or inorganic acid per equivalent of basic groups of the amino acids.
Suitable catalysts for the process of the invention are, for example, ruthenium, bimetallic ruthenium/metal X catalysts and trimetallic ruthenium/metal X/metal Y catalysts, which can all be used as such or applied to a support material. The metals X and Y can each be, for example, a metal selected from the group consisting of metals and transition metals having atomic numbers in the range from 23 to 82. The catalysts can contain ruthenium and, if desired, the metals X and, if desired, the metals Y in various forms, for example in elemental form, in the form of compounds of ruthenium or of ruthenium and the metals X or of ruthenium and the metals X and Y or in the form of an intermetallic compound of ruthenium and the metal X and, if desired, the metal Y. If the catalysts are not used in supported form, they can be present, for example, in colloidal form or as finely divided solid. Examples of catalysts are finely divided ruthenium/rhenium, ruthenium/osmium, ruthenium/iron, ruthenium/cobalt, ruthenium/rhodium, ruthenium/palladium, ruthenium/platinum, ruthenium/copper, ruthenium/zinc, ruthenium/silver, ruthenium/tin, ruthenium/germanium, ruthenium/gallium, ruthenium/lead, ruthenium/rhenium/copper, ruthenium/rhenium/silver and ruthenium/rhenium/tin particles, for example in metallic form or in the form of their oxides, hydroxides, halides, nitrates, carboxylates, acetylacetonates or as amine complexes.
Suitable support materials are, for example, carbons, carbon blacks, graphites, aluminium oxides, silicon dioxides, silicates, zeolites and clays. Supported catalysts may contain, for example, from 1 to 50% by weight of metal in elemental form or in the form of compounds.
The catalysts to be used may, if desired, have been modified by treatment with sulphur compounds, e.g. thioethers.
Preference is given to catalysts which contain ruthenium and rhenium without a support and as bimetallic catalyst particles have a high specific surface area, e.g. from 50 to 150 m
2
/g. Such catalysts can be prepared, for example, by reductively precipitating rhenium from a rhenium solution onto a ruthenium oxide hydrate having a high surface area (e.g. from 50 to 300 m
2
/g) by action of hydrogen. This gives a bimetallic catalyst having a high surface area and intimate contact between the two metals. Surprisingly, the reduction of the dissolved rhenium can be carried out in the presence of ruthenium at significantly lower temperatures than in the absence of ruthenium. In principle, the deposition of a second metal can be carried out as part of the catalyst preparation or in situ in the hydrogenation reaction.
Based on 1 mol of optically active amino acid used, the amount of catalyst employed can be, for example, from 0.1 to 10 g of metal or metal compounds or from 1 to 50 g of supported catalysts containing metal or metal compounds.
The process of the invention is generally carried out in the presence of a solvent for the optically active amino acids and optically active amino alcohols. Suitable solvents are, for example, water, water-miscible organic solvents and mixtures of the two. As water-miscible solvents, mention may be made of lower alcohols and water-miscible ethers. Preferred solvents are water and mixtures containing water and lower alcohols or tetrahydrofuran.
The process of the invention can be carried out, for example, at temperatures in the range from 0 to 150° C. and pressures in the range from 5 to 300 bar. Preference is given to temperatures of from 0 to 130° C. and pressures of from 10 to 280 bar. Particular preference is given to temperatures of from 30 to 80° C. and pressures of from 150 to 250 bar. It is also possible, if desired, to commence the reduction with hydrogen at a relatively low pressure, e.g. at from 50 to 150 bar, and then to complete it at relatively high pressures, e.g. from 150 to 300 bar. The reaction is complete when no more hydrogen is taken up, which is generally the case after from 1 to 10 hours. At low pressures and low temperatures, the reaction time can also be longer.
To work up the reaction mixture, it is possible, for example, firstly to cool the reaction mixture, to separate off the catalyst, e.g. by filtration, to remove the volatile constituents present (generally solvents and water of reaction) partially or completely by distillation, if desired under reduce

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