Method for producing optically active .alpha.-hydroxy acid or .a

Details Method for producing optically active .alpha.-hydroxy acid or .a Method for producing optically active .alpha.-hydroxy acid or .a

1995-11-09

1998-04-07

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435129, 435130, 435136, 435146, 422 8203, C12P 4100, C12P 1302, C12P 1100, C12P 740

Patent

active

057363854

ABSTRACT:
A reaction system, wherein a cyanohydrin is converted into an optically active .alpha.-hydroxy acid or .alpha.-hydroxyamide via a treatment with a microorganism, is provided with an automatic cyanohydrin controller comprising a cyano ion detector, a regulator and a cyanohydrin supplier linked thereto. The reaction is performed while automatically controlling the cyanohydrin concentration.
Thus cyanohydrin can be supplied under automatic control at a relatively low and constant concentration on the basis of its consumption ratio. The reaction rate of the catalyst can be continuously regarded as the rate-limiting factor. As a result, a decrease in the enzymatic activity during the reaction can be suppressed and an optically active .alpha.-hydroxy acid or .alpha.-hydroxyamide can be efficiently obtained at a high yield.

REFERENCES:
patent: 4351743 (1982-09-01), Hashimoto
patent: 5283193 (1994-02-01), Yamamoto et al.
patent: 5326702 (1994-07-01), Endo et al.
Process Biochemistry, 1980, pp. 18-23, D.B. Kell E.A., `The Role of Ion-Selective Electrodes in Improving Fermentation Yields`.

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