Method for producing optically active...

Details Method for producing optically active... Method for producing optically active...

2006-02-14

2006-02-14

Carr, Deborah D. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C554S141000

Reexamination Certificate

active

06998495

ABSTRACT:
A method for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative is provided. The method, which requires neither an ultralow-temperature reactor, an incubator, nor protection of the 5-position hydroxy group, is simple and economical.An optically active 3,5-dihydroxyhexanoic acid derivative is produced by asymmetrical hydrogenation of an optically active 3-oxo-5-hydroxyhexanoic acid derivative catalyzed by an RuBr2BINAP complex prepared from a ruthenium complex and a ruthenium-optically active phosphine complex, i.e., 2,2′-bisdiarylphosphino-1,1′-binaphthyl (BINAP), while using extremely inexpensive hydrogen as the reductant.

REFERENCES:
patent: 4739084 (1988-04-01), Takaya et al.
patent: 05-308977 (1993-11-01), None
patent: WO 92/10461 (1992-06-01), None
patent: WO 92/10503 (1992-06-01), None
International Search Report From Corresponding International Application No. PCT/JP02/11036, Dated Mar. 4, 2003, 1 Page.

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