Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1984-07-25
1988-02-09
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514561, 514728, A61K 3120, A61K 31195, A61K 31045
Patent
active
047242302
ABSTRACT:
An improved method is described for producing oncolysis, including regression of malignant tumors or other malignant conditions, without adverse effects upon normal body cells. In addition to a calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrate, administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation (most preferably 2,4-dinitrophenol), there is also concurrently administered a selected amount of a substantially non-toxic fatty acid oxidation inhibitor capable of effectively lowering the mitochondrial .beta.-oxidation rate of fatty acids.
REFERENCES:
patent: 4196300 (1980-04-01), Mohrbacher et al.
Weber, G., "Biochemical Strategy of Cancer Cells and the Design of Chemotherapy: G.H.A. Clowes Memorial Lecture", Cancer Research 43: 3466-3492 (Aug. 1983).
Wesdorp, R.I.C. et al., "Cancer Cachexia and its Nutritional Implications" Br. J. Sur. 70(6): 352-355 (Jun. 1983).
King, M. M., et al., "Modulation of Tumor Incidence and Possible Mechanisms of Inhibition of Mammary Carcinogensis by Dietary Antioxidents", Cancer Research (Suppl.) 43: 2485s-2490s (May 1983).
Rogers, A. E., "Influence of Dietary Content of Lipids and Liptropic Nutrients on Chemical Carcinogensis in Rats", Cancer Research (Suppl.) 43: 2477s-2484s (May 1983).
Weinhouse, S., "Changing Perceptions of Carbohydrate Metabolism in Tumors". Molecular Interrelations of Nutrition and Cancer, edited by M. S. Arnott, et al., Raven Press, New York (1982) pp. 167-181.
Weber, G., "Differential Carboxydrate Metabolism in Tumor and Host", Molecular Interrelations of Nutrition and Cancer, edited by M. S. Arnott, Raven Press, New York (1982) pp. 191-208.
Kritchevsky, D., "Lipids and Cancer", Molecular Interrelations of Nutrition and Cancer, edited by M. S. Arnott, et al., Raven Press, New York, (1982) pp. 209-217.
Kidwell, W. R., et al., "Effect of Unsaturated Fatty Acids on the Development and Proliferation of Normal and Neoplastic Breast Epithelium", Molecular Interrelations of Nutrition and Cancer, edited by M. S. Arnott, et al., Raven Press, New York (1982) pp. 219-236.
Carroll, K. K., et al., "The Rolle of Lipids in Tumorigensis", Molecular Interrelations of Nutrition and Cancer, edited by M. S. Arnott, et al., Raven Press, New York (1982) pp. 237-245.
Lavietes, B. B., et al., "The Role of Lipid Metabolism in Neoplastic Differentiation", J. Theor. Biol. 85: 523-542 (1980).
Wicha, M. S., et al., "Effects of Free Fatty Acids on the Growth of Normal and Neoplastic Rat Mammary Epithelial Cells", Cancer Research 39: 426-435 (Feb. 1979).
Burns, C. P., et al., "Utilization of Long-Chain Free Fatty Acids and Glucose by Human Leukemic Blast Cells" Cancer Research 37: 1323-1327 (May 1977).
Burns C. P., et al., "Fatty Acid Utilization by L1210 Murine Leukemia Cells" Cancer Research 37: 1991-1997 (Jul. 1977).
Cederbaum; I. A., et al., "Fatty Acid Oxidation, Substrate Shuttles, and Activity of the Citric Acid Cycle in Hepatocellular Carcinomas of Varying Differentiation", Cancer Research 36: 2980-2987 (Sep. 1976).
Spector, A. A., et al., "Fatty Acid Metabolism in Tumors", Progr. biochem. Pharmacol., 10: 42-75 (Krager, Basel 1975).
Sabine, J. R., "Defective Control of Lipid Biosynthesis in Cancerous and Precancerous Liver" Progr. biochem. Pharmacol., 10: 269-307 (Krager, Basel 1975).
Carroll, K. K., "Dietary Fat in Relation to Tumorigensis", Progr. biochem. Pharmacol., 10: 308-353 (Krager, Basel 1975).
van Eys, J., "Nutrition and Neoplasia", Nutrition Reviews 40(12); 353-359 (1982).
Buzby, G. P., et al., "Host-Tumor Interaction and Nutrient Supply", Cancer 45(12): 2940-2948 (1980).
Littman, M. L., et al., "Effect of Cholesterol-Free, Fat-Free Diet and Hypocholesteremic Agents on Growth of Transplantable Animal Tumors", Cancer Chemotherapy Reports 50(1 and 2); 25-45 (1966).
Lehninger, A. "Oxidation of Fatty Acids in Animal Tissues" Chapter 18, (1982).
Olowe, U., et al., The Journal of Biological Chemistry 257(10): 5408-5413 (1982).
Raaka, B. M. et al., The Journal of Biological Chemistry 254(9): 3303-3310 (1979).
Raaka, B. M., et al., The Journal of Biological Chemistry 254(14): 6755-6762 (1979).
Fong, J. C., et al., "On the Rate-Determining Step of Fatty Acid Oxidation in Heart Inhibition of Fatty Acid Oxidation by 4-Pentenoic Acid", The Journal of Biological Chemistry, 253(19): 6917-6922 (1978).
Feldman, E. B., et al., "Circulating Lipids and Liproteins in Women with Metastaic Breast Carcinoma", J. Clin. Encrinol. & Metab. 33:8 (1971).
Weinhouse, S., "Metabolism and Isozyme Alterations in Experimental Hepatomas", Federation Proceedings 32(12): 2162-2167 (1973).
Kitada, S., et al., "Characterization of a Lipid Mobilizing Factor from Tumors", Golden Jubilee International Congress on Essential Fatty Acid and Prostaglandins, edited by R. T. Holman et al., Pergamon Press, New York, (1981).
Bloch-Frankethal, L., et al., "Fatty Acid Oxidation and Ketogensis in Transplantable Liver Tumors", Cancer Research 25(5): 732-36 (1965).
Merck Index, Tenth Ed., Merck & Co., Inc. Rahway, NJ (1983) (specific paragraph citations in main text, pp. 26-27).
Heatler P. G. Inhibition of Mitochondrial Functions, Pergamon, 1981.
Chemical Abstr. 73:12786f, 1970; 73:18358h, 1970; 69:65737q, 1968; and 70; 1785s, 1969.
Busch, H. An Introduction to Biochem. of Cancer Cell Ch. 10, Acad. Press, N.Y., 1962.
Demers, L. M. et al., Proc. Soc. Exper. Biol. M. 140:724, 1972.
Hemker, H. C. BBA 48:221, 1961.
Haskell Cancer Treatment, Saunder Co. Pa., 2nd ed. 1985, Chg. to 76, pp. 889-896.
Brown J. R.
Rollins John W.
Therapeutical Systems Corp.
LandOfFree
Method for producing oncolysis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for producing oncolysis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing oncolysis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1284030