Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1997-08-28
1999-11-30
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
604 53, 600562, 600595, 514561, 424 92, A61M 3100, A01N 3712, A61K 4900
Patent
active
059937793
ABSTRACT:
A method for producing a non-human animal suffering from a spinal cord injury, which comprises interrupting an aorta at least at two sites, thereby forming an isolated segment of the aorta including branched parts of radicular arteries feeding the spinal cord between the sites of interruption, bringing the spinal cord to ischemia, and regionally administering glutamic acid or aspartic acid to the segment and a method for evaluating a medicament for treating a spinal cord injury due to glutamic acid or aspartic acid, which comprises interrupting an aorta of a non-human animal at least at two sites, thereby forming an isolated segment of the aorta including branched parts of redicular arteries feeding the spinal cord between the sites of interruption, bringing the spinal cord to ischemia, and regionally administering glutamic acid or aspartic acid together with a medicament for treating a spinal cord injury to the segment or a method for evaluating a medicament for treating a spinal cord injury due to glutamic acid or aspartic acid, which comprises administering a medicament for treating a spinal cord injury to a non-human animal produced according to the above method.
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Campell Bruce R.
Chen Shin-Lin
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