Method for producing metal-interferon-.alpha. crystals

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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530419, 530427, C07K 1456

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active

056022328

ABSTRACT:
A method for producing a crystalline zinc interferon (IFN) .alpha.-2 comprising forming a soluble solution of IFN .alpha.-2 and a metal acetate salt under condtions wherein supersaturation and metal alpha interferon crystals occur.

REFERENCES:
patent: 2882034 (1959-04-01), Peterson et al.
patent: 4315852 (1982-02-01), Leibowitz et al.
patent: 4672108 (1987-06-01), Kung et al.
patent: 4853218 (1989-08-01), Yim et al.
patent: 4871538 (1989-10-01), Yim et al.
patent: 5441734 (1995-08-01), Reichert et al.
patent: 5460956 (1995-10-01), Reichert et al.
T. L. Nagabushan, et al. Characterization of Genetically Engineered .alpha.-2 Interferon, Interferon: Research and Regulatory Consideration, pp. 78-88 (1982).
David L. Miller et al. Crystallization of Recombinant Human leukocyte Interferon A, Science 215:689-690 (Feb. 5, 1982).
C. Weissmann, et al., Structure and Expression of human IFN-.alpha.genes, Phil. Trans. R. Soc. Lond. B299, 7-28 (1982).
Alexander McPherson, Preparation and Analysis of Protein Crystals. Hohn Wiley & Sons pp. 102-104. (1982).
David Olis et al. "Protein Crystallization": pp. 646-659; Guide to Protein Purification (Academic Press 1990).
Matsuda et al. "New Crystal Form of Recombinant Murine Interferon-.beta." J. Biol. Chem 264 (23): 13381-13382 (Aug. 1989).
Sano et al. "Crystallization of physiologically active proteins . . . " Nippon Kessho Seicho Gakkaishi 16(1):52-60 (1989).
Senda et al. "Three-dimensional Crystal Structure of Recombinant Murine Interferon-.beta." The EMBO 11(9):4193-3201 (Sep. 1992).
Lai et al. "Structure/function studies of murine interferon-.alpha.1 using site-directed mutagenesis followed by in vitro synthesis" Antiviral Res. 18: 65-76 (May 1992).
Waine et al., "Structure-Function Study of the Region Encompassing Resides 26-40 of Human Interferon-.alpha.4: Identification of Redidues Important for Antiviral and Antiproliferative Activities" J. Interfer. Res. 12:43-48 (Feb. 1992).
Zav'yalov et al. "Theoretical analysis of conformation and active sites of interferons" Immuno. Lett. 22: 173-182 (Jul. 1992).
Senda et al. "Three-dimensional Structure of Recombinant Murine Interferon-.beta." Proc. Japan Acad 66(4) Ser B::77-80 (1990).

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