Method for producing liposomes in selected size range

Details Method for producing liposomes in selected size range Method for producing liposomes in selected size range

1983-01-21

1985-07-16

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 424 38, 436829, B01J 1302, A61K 952

Patent

active

045295611

ABSTRACT:
Liposomes of uniform size are produced by forming liposomes in relatively random sizes, and extruding the liposomes under pressure through a uniform-pore-size membrane to force at least some of the liposomes into smaller sizes. Extrusion may be repeated to increase uniformity of the liposomes. The liposomes may contain an encapsulated drug.

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patent: 4078052 (1978-03-01), Papahadjopoulos
patent: 4089801 (1978-05-01), Schneider
Szoka, Jr. et al., "Procedure for Prep. of Liposomes . . . ", Proc. Natl. Acad. Sci. U.S.A.", vol. 75, No. 9, pp. 4194-4198, (Sep. 1978).
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Remington's Pharmaceutical Sciences, 14th Ed., 1970 (Mack Pub. Co., Easton, PA).
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