Method for producing lipoic acid and dihydrolipoic acid

Details Method for producing lipoic acid and dihydrolipoic acid Method for producing lipoic acid and dihydrolipoic acid

2005-06-14

2005-06-14

Carr, Deborah D. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C554S085000

Reexamination Certificate

active

06906210

ABSTRACT:
Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected froma) distillation of dihydrolipoic acid,b) reaction of or its stereoisomer, where Ms is SO2—R′ and R and R′ independently of one another is [sic] C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride,(c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or(d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5,or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.

REFERENCES:
patent: 2788355 (1957-04-01), Bullock
patent: 3132152 (1964-05-01), Ohara et al.
patent: 5281722 (1994-01-01), Blaschke et al.
patent: 5380920 (1995-01-01), Paust et al.
patent: 5530143 (1996-06-01), Balkenhohl et al.
patent: 5731448 (1998-03-01), Gewald et al.
patent: 42 29 914 (1994-03-01), None
patent: 487 986 (1992-06-01), None
patent: 543 088 (1993-05-01), None
patent: 763 533 (1997-03-01), None
patent: 996703 (1965-06-01), None
patent: 00/08012 (2000-02-01), None
XP-002188279, Reed et al.
XP 002022470, Acker et al.
XP 002197086, Gunsalus et al.
XP002197089.
XP-002197091.
A Short and Productive Synthesis . . . Bringmann et al.655-661.
J.Sci.&Ind.Res., vol. 49, 8/90,400-409, Yadav et al.
Tet.Ltr.vol. 30, No. 42,pp. 57-55708.
Chem.Soc.Perkin Trans.1988, Brookes et al, 9-12.
The Synthesis of (R)—(+)Lipoic . . . , Adger et al., 253-261, Bio.Med.Chem., vol. 5,No 2, 1997.
J.Chem.Soc.,Chem,1983, Brookes et al.,1051-1053.
Abst.JP 1960-35704.
XP-002197090.
XP-002197087.
XP-002197088.

Affiliated with

Also associated with

Rating

Method for producing lipoic acid and dihydrolipoic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing lipoic acid and dihydrolipoic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing lipoic acid and dihydrolipoic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3474049