Method for producing L-lysine

Details Method for producing L-lysine Method for producing L-lysine

2010-03-11

2011-11-22

Robinson, Hope (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

C435S252000, C435S325000, C435S007100

Reexamination Certificate

active

08062869

ABSTRACT:
AnEscherichiabacterium having dihydrodipicolinate synthase and aspartokinase, both of which are desensitized to feedback inhibition by L-lysine. The intracellular activity of dihydrodipicolinate reductase in this bacterium can also be enhanced. Furthermore, a diaminopimelate dehydrogenase gene can be introduced into this bacterium, or intracellular activities of tetrahydrodipicolinate succinylase and succinyl diaminopimelate deacylase can be enhanced. Finally, the intracellular activities of aspartate-semialdehyde dehydrogenase or phosphoenolpyruvate carboxylase can be enhanced in this bacterium. The bacterium can be cultured in a suitable medium to produce and accumulate L-lysine in culture, and the L-lysine is collected from the culture.

REFERENCES:
patent: 4346170 (1982-08-01), Sano et al.
patent: 5827698 (1998-10-01), Kikuchi et al.
patent: 5830716 (1998-11-01), Kojima et al.
patent: 5876983 (1999-03-01), Sugimoto et al.
patent: 5919694 (1999-07-01), Sugimoto et al.
patent: 5932453 (1999-08-01), Kikuchi et al.
patent: 6040160 (2000-03-01), Kojima et al.
patent: 6200785 (2001-03-01), Kreutzer et al.
patent: 7090998 (2006-08-01), Ishikawa et al.
patent: 7097999 (2006-08-01), Tsujimoto et al.
patent: 7252972 (2007-08-01), Kikuchi et al.
patent: 7306933 (2007-12-01), Van Dien et al.
patent: 7399617 (2008-07-01), Livshits et al.
patent: 7524656 (2009-04-01), Livshits et al.
patent: 7527950 (2009-05-01), Livshits et al.
patent: 2002/0110876 (2002-08-01), Miyata et al.
patent: 2002/0160461 (2002-10-01), Nakai et al.
patent: 2003/0049804 (2003-03-01), Pompejus et al.
patent: 2004/0126854 (2004-07-01), Hanke et al.
patent: 2004/0265956 (2004-12-01), Takikawa et al.
patent: 2006/0019367 (2006-01-01), Umezawa et al.
patent: 2006/0205043 (2006-09-01), Tsujimoto et al.
patent: 2007/0184525 (2007-08-01), Date et al.
patent: 2007/0254345 (2007-11-01), Fukui et al.
patent: 2009/0148915 (2009-06-01), Van Dien et al.
patent: 38 23 451 (1990-01-01), None
patent: 0 318 663 (1989-06-01), None
patent: 0 723 011 (1996-07-01), None
patent: 0 733 710 (1996-09-01), None
patent: 0 733 712 (1996-09-01), None
patent: 95/16042 (1995-06-01), None
Chatterjee, M., et al., “Microbial Production of L-lysine: A Review,” Hind. Antibiot. Bull. 1997, vol. 39, pp. 20-49.
Jetten, M. S. M., et al., “Recent Advances in the Physiology and Genetics of Amino Acid-Producing Bacteria,” Critical Rev. Biotechnol. 1995;15(1):73-103.
Vauterni, M., et al., “Functional rescue of a bacterialdapAauxotroph with a plant cDNA library selects for mutant clones encoding a feedback-insensitive dihydrodipicolinate synthase,” The Plant Journal 2000;21(3):239-248.
English translation of Third Party Letter (Degussa) to European Patent Office concerning the patentability of the invention, dated Jul. 26, 2007, pp. 1-7.
Office Communication from EP Patent App. No. 00900872.3 (Sep. 17, 2007).
Supplementary European Search Report for EP Patent App. No. 00900872.3 (Jun. 23, 2004).

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