Method for producing L-isoleucine by fermentation

Details Method for producing L-isoleucine by fermentation Method for producing L-isoleucine by fermentation

1982-06-25

1984-04-10

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435172, 435253, C12P 1306, C12N 1500, C12N 120

Patent

active

044422083

ABSTRACT:
L-isoleucine is produced by a fermentation process comprising aerobically culturing in an aqueous culture medium an L-isoleucine producing microorganism obtained by isolating a transformed strain resistant to .alpha.-amino-.beta.-hydroxy valeric acid prepared by incorporating into a recipient strain of the genus Brevibacterium orCorynebacterium, which is sensitive to .alpha.-amino-.beta.-hydroxy valeric acid, a plasmid DNA obtained from a microorganism of the genus Brevibacterium or Corynebacterium into which has been inserted a fragment of chromosomal DNA derived from a DNA-donor strain of the genus Brevibacterium or Corynebacterium which is resistant to .alpha.-amino-.beta.-hydroxy valeric acid; and recovering L-isoleucine which accumulates in the resulting culture liquid.

REFERENCES:
patent: 4237228 (1980-12-01), Zhdanova et al.
patent: 4329427 (1982-05-01), Updike et al.
patent: 4346170 (1982-08-01), Sano et al.
patent: 4347318 (1982-08-01), Miwa et al.

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