Method for producing L-ascorbic acid 2-phosphates

Details Method for producing L-ascorbic acid 2-phosphates Method for producing L-ascorbic acid 2-phosphates

1990-06-25

1992-05-05

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07F 906

Patent

active

051109514

ABSTRACT:
A method for producing L-ascorbic acid 2-phosphates, is disclosed which comprises phosphorylating L-ascorbic acid whose hydroxyl groups at the 5- and 6-positions are unprotected or protected with a protective group, or salts thereof, with a phosphorus oxyhalide to form corresponding L-ascorbic acid 2-phosphates, wherein a reaction mixture obtained after the phosphorylation reaction is heated to convert by-products derived from L-ascorbic acid into L-ascorbic acid, which again is subjected to the phosphorylation reaction with the phosphorus oxyhalide. The method produce L-ascorbic acid 2-phosphates in a high yield and at a high purity with simple operations.

REFERENCES:
patent: 3658848 (1972-04-01), Nomura et al.
patent: 3671549 (1972-06-01), Hinkley
patent: 4179445 (1979-12-01), Sieb et al.
Chem. Pharm. Bull., 19(7) 1433-1437, (1971).

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