Method for producing immunosuppressive agents

Details Method for producing immunosuppressive agents Method for producing immunosuppressive agents

1991-12-09

1993-03-30

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530350, 530351, 530395, 530412, 530413, 435 681, A23J 100, C07K 300, A01N 3718, C12P 2100

Patent

active

051985381

ABSTRACT:
The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and isolating the unreduced N-linked oligosaccharides from an extract of said preparation.

REFERENCES:
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Chaouat and Monnot, Am. J. Reprod. Immunol. 6, 5-8 (1984).
Mowbray et al., Lancet, Apr. 27, 1987, pp. 941-943.
Jenkins et al., Brit. Med. J. 1, 542-544 (1978).
Muchmore & Decker, Science 229, 479-481 (1985).
Muchmore & Decker, J. Immunol. 138, 2541-2546 (1987).
Muchmore et al., J. Immunol. 18, 2547-2553 (1987).
Hession et al., Science, 237, 1479-1484 (1987).
Smith et al., Nature 252, 302-303 (1974).
Pennica et al., Science, 236, 83-88 (1987).

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