Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1995-05-04
2000-04-04
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435 691, 435 697, 435 7023, 4353201, 435419, 435468, 800278, 536 243, 536 235, 536 2353, 536 241, C12N 1500, C12N 1529, C12N 1582, A01H 400
Patent
active
060460377
ABSTRACT:
The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.
The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.
The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
REFERENCES:
patent: 4443549 (1984-04-01), Sadowski
patent: 4594244 (1986-06-01), Lehner et al.
patent: 4607388 (1986-08-01), Koiyumaki et al.
patent: 4652448 (1987-03-01), Sadowski
patent: 4736866 (1988-04-01), Leder et al.
patent: 4870009 (1989-09-01), Evans et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 5034322 (1991-07-01), Rogers et al.
patent: 5183756 (1993-02-01), Schlom
patent: 5188642 (1993-02-01), Shah et al.
patent: 5349124 (1994-09-01), Fischhoff et al.
patent: 5352440 (1994-10-01), Gilchrest et al.
patent: 5352446 (1994-10-01), Lehner
patent: 5352605 (1994-10-01), Fraley et al.
During et al. Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Molecular Biology 15: 281-293, 1990.
Bakos et al. Expression and purification of biologically active domain I of the human polymeric immunoglobulin receptor. Molecular Immunology. vol. 31, No. 2, pp. 165-168, May 1994.
Crago et al., "Antisera to the secretory component recognize the murine Fc receptor for IgA," Journal of Immunology 142(11):3909-3912 (1989).
During et al., "Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum," Plant Molecular Biology 15:281-293 (1990).
During, "Wundinduzierbare expression und sekretion von T4 lysozym and monoklonalen antikorpern in Nicotiana tabacum," Inaugural Dissertation (1988).
Eliasson et al., "Chimeric IgG-binding receptors engineered from staphylococcal protein A and streptococcal protein G," Journal of Biological Chemistry 263(9):4323-4327 (1989).
Hiatt et al., "Characterization and Applications of Antibodies Produced in Plants," Intern. Rev. Immunol. 10: 139-152 (1993).
Kraehenbul et al, "Receptor-mediated transepithelial transport of secretory antibodies and engineering of mucosal antibodies," Advances in Experimental Medicine and Biology 216B:1053-1060 (1987).
Solari et al., "Cellular location of the cleavage event of the polymeric immunoglobulin receptor and fate of its anchoring domain in the rat hepatocyte," Biochemical Journal 257:759-768 (1989).
Larrick, J. W. and R. Balint, "Recombinant Therapeutic Human Monoclonal Antibodies," The Pharmacology of Monoclonal Antibodies, Chapter 2, pp. 23-48, M. Rosenberg and G.P. Moore eds., Springer-Verlag, Berlin (1994).
Mark, G. E. and E. A. Padlan, "Humanization of Monclonal Antibodies," The Pharmacology of Monoclonal Antibodies, Chapter 4, pp. 105-134, M. Rosenberg and G.P. Moore eds., Springer-Verlag, Berlin (1994).
Hiatt, A. and M. Hein, "Structure, Function and Uses of Anitbodies from Transgenic Plants and Animals," The Pharmacology of Monoclonal Antibodies, Chapter 12, pp. 317-330, M. Rosenberg and G.P. Moore eds., Springer-Verlag, Berlin (1994).
Mostov, Keith A., "Transepithelial transport of immunoglobulins," Ann. Rev. Immol., 12:63-84 (1994).
Carayannopoulos, L. et al., "Recombinant human IgA expressed in insect cells," Proc. Natl. Acad. Sci. U.S.A., 91:8348-8352 (1994).
Huang, Ann L. et al., "Glucocorticoid Regulation of the Ha-MuSV p21 Gene Conferred by Sequences from Mouse Mammary Tumor Virus," Cell, 27:245-255 (1981).
Benfey, Philip N. et al., "The Cauliflower Mosaic Virus 35S Promotor: Combinatorial Regulation of Transcription in Plants," Science, 250:959-966 (1990).
Paszkowski, Jerzy et al., "Direct gene transfer to plants," The EMBO Journal, 3:2717-2722 (1989).
Odell, Joan T. et al., "Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter," Nature, 313:810-812 (1985).
Benfey, Philip N. et al., "Regulated Genes in Transgenic Plants," Science, 244:174-181 (1989).
Mostov, Keith E. et al., "The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains," Nature, 308:37-43 (1984).
Krajci, Peter et al., "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)," Eur. J. Immunol., 22:2309-2315 (1992).
Krajci, Peter et al., "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues," Biochem. Biophys. Res. Comm., 158:783-789 (1989).
Kraehenbuhl, Jean-Pierre et al., "Transepithelial transport and mucosal defence II: secretion of IgA," Trends in Cell Biol., 2:170-174 (1992).
Banting, George et al., "Intracellular targetting signals of polymeric immunoglobulin receptors are highly conserved between species," FEBS Letters, 254:177-183 (1989).
Piskurich, J. F. et al., "Molecular Cloning of Mouse Polymeric Ig Receptor cDNA," J. Immunol., 150:38, Abstract 203 (1993).
Verbeet et al., GenBank Accession No. X81371.
Williams, Alan F. et al., "The Immunoglobulin Superfamily" Immunoglobulin Genes, Chap. 19, pp. 361-387, Academic Press (Honjo, Alt and Rabbits, Eds. 1989).
Huse, William D. et al., "Generation of a Large Combinatorial Library of the Immunboglobulin Repertoire in Phage Lambda," Science, 246:1275-1281 (1989).
Koshland, Marian Elliot, "The Immunoglobulin Helper: The J Chain," Immunoglobulin Genes, Chap. 18, pp. 345-359, Academic Press (Honjo, Alt and Rabbits, Eds. 1989).
Matsuuchi, Linda et al., "Immunoglobulin J chain gene from the mouse," Proc. Natl. Acad. Sci. U.S.A., 83:456-460 (1986).
Marshall, R. D., "Glycoproteins," Annual Review of Biochemistry, 41:673-702, Annual Reviews Inc. (Snell, Boyer, Meister, and Sinsheimer, Eds. 1972).
Marshall, R. D., "The Nature and Metabolism of the Carbohydrate-Peptide Linkages of Glycoproteins," Biochem. Soc. Symp., 40:17-26 (1974).
Ma, J. K-C. et al., "Specificity of monolconal antibodies in local passive immunization against Streptococcus mutans," Clin. Exp. Immunol. 77:331-337 (1989).
Ma. J. K-C. et al., "Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants," Eur. J. Immunol. 24:131-138 (1994).
Kobayashi, Kunihiko et al., "Studies on human secretory IgA (II). Comparative studies on a fragment of secretory component derived from secretory IgA and fragments obtained by enzymatic digestion of free secretory component," Immunochemistry, 10:73-80 (1973).
McNabb, Paul C. et al., "Host Defense Mechanisms at Mucosal Surfaces," Ann. Rev. Microbiol., 35:477-496 (1981).
Silbart, Lawrence K. et al., "Reduction of Intestinal Carcinogen Absorption by Carcinogen-Specific Secretory Immunity," Science, 243:1462-1464 (1989).
Orlandi, Rosaria et al., "Cloning immunoglobulin variable domains for expression by the polymerase chain reaction," Proc. Natl. Acad. Sci. U.S.A., 86:3833-3837 (1989).
Hiatt, Andrew, "Production of antibodies in transgenic plants," Nature, 342:76-78 (1989).
Smith, Roberta and T. Lehner, "Characterisation of monoclonal antibodies to common protein epitopes on the cell surface of Streptococcus mutans and Streptocuccus sobrinus," Oral Microbiol. Immunol., 4:153-158 (1989).
Rogers, S. G. et al., "Improved Vectors for Plant Transformation: Expression Cassette Vectors and New Selectable Markers," Methods in Enzymology, 153:253-277 (1987).
Cocking and Davey, "Gene Transfer in Cereals," Science, 236:1259-1262 (1987).
Spielmann, Albert et al., "T-DNA structure in transgenic tobacco pl
Hiatt Andrew C.
Lehner Thomas
Ma Julian K.-C.
Mostov Keith E.
Haas Thomas
Smith Lynette F.
LandOfFree
Method for producing immunoglobulins containing protection prote does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for producing immunoglobulins containing protection prote, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing immunoglobulins containing protection prote will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-364213