Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-05-01
2007-05-01
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S468000
Reexamination Certificate
active
10781989
ABSTRACT:
The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such asS. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
REFERENCES:
patent: 4443549 (1984-04-01), Sadowski et al.
patent: 4594244 (1986-06-01), Lehner et al.
patent: 4607388 (1986-08-01), Koiyumaki et al.
patent: 4652448 (1987-03-01), Sadowski
patent: 4736866 (1988-04-01), Leder et al.
patent: 4870009 (1989-09-01), Evans et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 5034322 (1991-07-01), Rogers et al.
patent: 5183756 (1993-02-01), Schlom
patent: 5188642 (1993-02-01), Shah et al.
patent: 5202422 (1993-04-01), Hiatt et al.
patent: 5349124 (1994-09-01), Fischloff et al.
patent: 5352440 (1994-10-01), Gilchrest et al.
patent: 5352446 (1994-10-01), Lehner
patent: 5352605 (1994-10-01), Fraley et al.
patent: 5854402 (1998-12-01), Lehner et al.
patent: 5959177 (1999-09-01), Hein et al.
patent: 6046037 (2000-04-01), Hiatt et al.
patent: 6303341 (2001-10-01), Hiatt et al.
patent: 6417429 (2002-07-01), Hein et al.
patent: 6852319 (2005-02-01), Hein et al.
patent: 484 148 (1992-05-01), None
patent: 0 371 017 (1994-09-01), None
patent: 480014 (1996-11-01), None
patent: 87/00551 (1987-01-01), None
patent: 88/06455 (1988-09-01), None
patent: 90/14430 (1990-11-01), None
patent: 91/06320 (1991-05-01), None
patent: 91/16061 (1991-10-01), None
patent: WO-96/21012 (1996-07-01), None
Abdullah, Ruslan et al., “Efficient Plant Regeneration from Rice Protoplasts Through Somatic Embryogenesis,” Biotechnology, 4:1087-1090 (1986).
Bakos et al. Expression and purification of biologically active domain 1 of the human polymeric immunoglobulin receptor. Molecular Immunology. vol. 31, No. 2, pp. 165-168, May 1994.
Banting, George et al., “Intracellular targetting signals of polymeric immunoglobulin receptors are highly conserved between species,” FEBS Letters, 254:177-183 (1989).
Barnes, Wayne M., “Variable patterns of expression of luciferase in transgenic tobacco leaves,” Proc. Natl. Acad. Sci. USA, 87:9183-9187 (1990).
Benbrook, Charles M. et al., “Herbicide Resistance: Environmental and Economic Issues,” in Proceedings Bio Expo 1986, Butterworth, Stoneham, MA, pp. 27-54 (1986).
Benfey, Philip N. et al., “Regulated Genes in Transgenic Plants,” Science, 244:174-181 (1989).
Benfey, Philip N. et al., “The Cauliflower Mosaic Virus 35S Promotor: Combinatorial Regulation of Transcription in Plants,” Science, 250:959-966 (1990).
Brandtzaeg, P. & Prydz, H., “Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins,” Nature, 311:71-73 (1984).
Bytebier, Benny et al., “T-DNA organization in tumor cultures and transgenic plants of the monocotyledon Asparagus officinalis,” Proc. Natl. Acad. Sci. USA, 84:5345-5349 (1987).
Callis, Judy et al., “Introns increase gene expression in cultured maize cells,” Genes and Development, 1:1183-1200 (1987).
Carayannopoulos, L. et al., “Recombinant human IgA expressed in insect cells,” Proc. natl. Acad. Sci. U.S.A., 91:8348-8352 (1994).
Cocking and Davey, “Gene Transfer in Cereals,” Science, 236:1259-1262 (1987).
Corthesy, B. et al., “Biochemical Characterisation of Recombinant Secretory component,” Experientai, 50:A27, Abstract S08-08 (1994).
Crago et al., “Antisera to the secretory component recognize the murine Fc receptor for IgA,” Journal of Immunology 142(11):3909-3912 (1989).
de la Pena, A. et al., “Transgenic rye plants obtained by injecting DNA into young floral tillers,” Nature, 325:274-276 (1987).
During et al. Synthesis and self-assembly of a functional monoclonal antibody in transgenicNicotiana tabacum. Plant Molecular Biology 15: 281-293, 1990.
During et al., “Synthesis and self-assembly of a functional monoclonal antibody in transgenicNicotiana tabacum,” Plant Molecular Biology 15:281-293 (1990).
During, “Wundinduzierbare expression und sekretion von T4 lysozym and monoklonalen antikorpern inNicotiana tabacum,” Inaugral Dissertation (1988).
Eliasson et al., “Chimeric IgG-binding receptors engineered from staphylococcal protein A and streptococcal protein G,” Journal of Biological Chemistry 263(9):4323-4327 (1989).
Fraley, Robert T. et al., “Expression of bacterial genes in plant cells,” Proc. Natl. Acad. Sci. U.S.A., 80:4803-4807 (1983).
Fromm, Michael E. et al., “Stable transformation of maize after gene transfer by electroporation,” Nature, 319:791-793 (1986).
Hein, Mich B. et al., “Evaluation of Immunoglobulins from Plant Cells,” Biotechnol. Prog., 7:455-461 (1991).
Hess, Dieter, “Pollen-Based Techniques in Genetic Manipulation,” International Review of Cytology, 107:367-395 (1987).
Hiatt et al., “Characterization and Applications of Antibodies Produced in Plants,” Intern. Rev. Immunol. 10: 139-152 (1993).
Hiatt, A. and M. Hein, “Structure, Function and Uses of Anitbodies from Transgenic Plants and Animals,” The Pharmacology of Monoclonal Antibodies, Chapter 12, pp. 317-330, M. Rosenberg and G.P. Moore eds., Springer-Verlag, Berlin (1994).
Hiatt, A. et al., “Monoclonal antibody engineering in plants,” FEBS Letters, 307(1):71-75 (1992).
Hiatt, Andrew, “Production of antibodies in transgenic plants,” Nature, 342:76-78 (1989).
Horsch, R. B. et al., “A Simple and General Method for Transferring Genes into Plants,” Science, 227:1229-1231 (1985).
Huang, Ann L. et al., “Glucocorticoid Regulation of the Ha-MuSV p21 Gene Conferred by Sequences from Mouse Mammary Tumor Virus,” Cell, 27:245-255 (1981).
Huse, William D. et al., “Generation of a Large Combinatorial Library of the Immunoboglobulin Repertoire in Phage Lambda,” Science, 246:1275-1281 (1989).
Jorgensen, Richard et al., “T-DNA is organized predominantly in inverted repeat structures in plants transformed withAgrobacterium tumefaciensC58 derivatives,” Mol. Gen. Genet., 207:471-477 (1987).
Klein, T. M. et al., “High-velocity microprojectiles from delivering nucleic acids into living cells,” Nature, 327:70-73 (1987).
Klein, Theodore M. et al., “Stable genetic transformation of intactNicotianacells by the particle bombardment process,” Proc. natl. Acad. Sci. U.S.A., 85:8502-8505 (1988).
Kobayashi, Kunihiko et al., “Studies on human secretory IgA (II). Comparative studies on a fragment of secretory component derived from secretory IgA and fragments obtained by enzymatic digestion of free secretory component,” Immunochemistry, 10:73-80 (1973).
Koshland, Marian Elliot, “The Immunoglobulin Helper: The J Chain,” Immunoglobulin Genes, Chap. 18, pp. 345-359, Academic Press (Honjo, Alt and Rabbits, Eds. 1989).
Kraehenbuhl, Jean-Pierre et al., “Transepithelial transport and mucosal defence II: secretion of IgA,” Trends in Cell Biol., 2:170-174 (1992).
Kraehenbul et al, “Receptor-mediated transepithelial transport of secretory antibodies and engineering of mucosal antibodies,” Adv
Hiatt Andrew C.
Lehner Thomas
Ma Julian K.-C.
Mostov Keith E.
Salimi Ali R.
The Regents of the University of California
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