Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1992-04-27
1994-12-27
Stone, Jacqueline
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351723, 4352401, 4352402, 935 62, 935 71, 935 93, C12N 1563, C12N 510, A61K 4800
Patent
active
053765427
ABSTRACT:
A process of immortalizing cells with isolated HPV-16, 18, 31, 33 or 35 E6 and E7 genes or the E7 gene alone to produce non-tumorigenic immortalized cell lines which retain the differentiated phenotypic characteristics of the parent cells.
REFERENCES:
Neoplastic Transformation in Human Cell Culture, copyright 1991 by The Humana Press Inc., Papers from a workshop held at Georgetown University Medical Center, Washington, D.C. on Apr. 25-26, 1991.
Abstracts of papers presented at the 1991 Papillomavirus Workshop Jul. 20-26, 1991 in Seattle, Washington on the campus of the University of Washington.
Inverse Relationship between Human Papillomavirus Type 16 Early Gene Expression and Cell Differentiation in Nude Mouse Epithelial Cysts and Tumors Induced by HPV-Positive Human Cell Lines, vol. 65, No. 2, Journal of Virology, Feb. 1991, pp. 796-804.
Notes on the E6 and E7 Genes of the Human Papillomavirus Type 16 Together Are Necessary and Sufficient for Transformation of Primary Human Keratinocytes, vol. 63, No. 10, Journal of Virology, Oct. 1989, pp. 4417-4421.
Short Report on the E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes, The Macmillan Press Ltd. 1989, Oncogene (1989), 4, 1529-1532.
Differences in Transformation Activity between HPV-18 and HPV-16 Map to the Viral LCR-E6-E7 Region, Virology 181, 374-377 (1991) by Lusia Lina Villa and Richard Schlegel.
Immortalization and Altered Differentiation of Human Keratinocytes in Vitro by the E6 and E7 Open Reading Frames of Human Papillomavirus Type 18, vol. 64, No. 2, Journal of Virology, Feb. 1990, pp. 519-526.
Altered Expression of Proliferation and Differentiation Markers in HJuman Papillomavirus 16 and 18 Immortalized Epithelial Cells Grown in Organotypic Culture, American Journal of Pathology, vol. 140, No. 1, Jan. 1992.
The E7 Gene of Human Papillomavirus Type 16 is Sufficient for Immortalization of Human Epithelial Cells, Journal of Virology, Jan. 1991, pp. 473-478, vol. 65, No. 1.
Immortalization of Normal Human Bronchial Epithelial Cells by Human Papillomaviruses 16 or 18, Cancer Research 51, 5370-5377, Oct. 1, 1991.
Loss of p53 Protein in Human Papillomavirus Type 16 E6-Immortalized Human Mammary Epithelial Cells, vol. 65, No. 12, Journal of Virology, Dec. 1991, pp. 6671-6676.
Human Cervical and Foreskin Epithelial Cells Immortalized by Human Papillomavirus DNAs Exhibit Dysplastic Differentiation in Vivo, Cancer Research 50, 3709-3715, Jun. 15, 1990.
In Vitro Biological Activities of the E6 and E7 Genes Vary among Human Papillomaviruses of Different Oncogenic Potential, Journal of Virology, Jan. 1991, pp. 292-298, vol. 65, No. 1.
Epithelial Cells Immortalized by Human Papillomaviruses Have Premalignant Characteristics in Organotypic Culture, American Journal of Pathology, vol. 138, No. 3, Mar. 1991, pp. 673-685.
Georgetown University
Stone Jacqueline
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