Method for producing human nerve growth factor 2

Details Method for producing human nerve growth factor 2 Method for producing human nerve growth factor 2

1995-01-23

1997-06-17

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Vector, per se

435694, 4352542, 435325, 435364, 435367, 435360, 435354, 435357, 435355, C12N 1579, C12N 116, C12N 510, C12N 2100

Patent

active

056396643

ABSTRACT:
A transformant, which harbors a recombinant vector containing a DNA which codes for human nerve growth factor 2 and a DNA which codes for the pro-region of a nerve growth factor at 5'-terminal of said DNA, produces human nerve factor 2 in stable and large amount in a culture medium.

REFERENCES:
Ullrich et al., "Human B-nerve growth factor gene sequence highly homologous to that of mouse" Nature, vol. 30, 1983 pp. 821-825.
Kaisho et al., "Cloning and expression of a cDNA encoding a novel human neurotrophic factor" FEBS Letters, vol. 266, 1990 pp. 187-191.
Hohn et al., "Identification and Characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family" Nature, vol. 344, 1990, pp. 339-341.
Maisonpierre et al. "Neurothrophin-3: A neurotrophic Factor Related to NGF and BDNF" Science, vol. 247 (1990) pp. 1446-1451.
Rosenthal et al. "Primary Structure and Biological Activity of a Novel Human Neutotrophic Factor" Neuron vol. 4 (1990) pp. 767-773.
Ernfors et al., "Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor" Proc. Nat'l. Acad. Sci. USA, vol. 87, (1990) pp. 5454-5458.
Jones et al., "Molecular cloning of a human gene that is a member of the nerve growth factor family" Proc. Nat'l. Acad. Sci. USA, vol. 87, (1990) pp. 8060-8064.
Sambrook et al. (1989), Molecular Cloning: A Laboratory Manual, 2nd ed. (Cold Spring Harbor Press, Cold Spring Harbor, N.Y.), pp. 16.30-16.36.

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