Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1985-12-10
1988-10-04
Phillips, Delbert R.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
530402, 530403, 530811, 530812, C08H 8900, C08H 100, C07G 700
Patent
active
047757140
ABSTRACT:
A two-step process of immobilization of biologically efficient compounds is disclosed, in which the biologically efficient compounds are bonded from an aqueous solution by a hydrolytically stable linkage to a macroporous polymeric carrier containing reactive functional groups. In the first step, a hydrophobic adsorption occurs of the biologically efficient compounds on a macroporous matrix of the carrier, and an increase of their concentration on the solid surface. In the second step, the reaction takes place with the reactive functional groups of the carrier, and a covalent linkage is formed. The hydrophobic adsorption of compounds determined for immobilization is achieved by the addition of inorganic salts in a concentration from 0.5 to 3.0 mol/l. The invention can be utilized in the preparation of enzymatic catalysts for transformations of compounds and in the preparation of specific sorbents for both analytical and preparative affinity chromatography. These methods are employed in the fields of biotechnology, chemical and clinical analysis, food industry, pharmacology and clinical therapy.
REFERENCES:
patent: 4104363 (1978-08-01), Vozka et al.
patent: 4440903 (1984-04-01), Golstein et al.
patent: 4511694 (1985-03-01), Kramer et al.
patent: 4563490 (1986-01-01), Stol et al.
Smalla et al., "Influence of Salts on the Covalent Immobilization of Proteins to Modified Copolymers of 2-Hydroxyethyl Methacrylate with Ethylene Dimethaerylate", Biochimica et Biophysiea Acta (Manuscript 1981).
Coupek Jiri
Hermann Peter
Smalla Kornelia
Turkova Jaroslava
Willhardt Ingo
Laboratorni pristroje, koncernovy podnik
Nutter Nathan M.
Phillips Delbert R.
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