Method for producing high potency factor VIII

Details Method for producing high potency factor VIII Method for producing high potency factor VIII

1978-12-04

1980-09-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, A61K 3514, C07G 700

Patent

active

042217806

ABSTRACT:
Factor VIII preparations of enhanced potency are obtained from human blood donors by recovering blood from donors who have been treated with 1-deamino-8-D-arginine vasopressin, in an amount sufficient to increase the circulating blood level of Factor VIII in the donor.

REFERENCES:
patent: 3497491 (1970-02-01), Zaoral et al.
patent: 4104266 (1978-08-01), Wickerhauser
Cort et al.--Molecular Endocrinology (1977), pp. 337-349.
Cash et al.--Clinical Science & Molecular Medicine, vol. 54, (1978), pp. 403-409.
Mannucci et al.--The Lancet-8017c, (1977), pp. 869-872.
Aberg et al.--Chem. Abst., vol. 84 (1976), p. 41626m.

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