Method for producing high potency factor VIII

Details Method for producing high potency factor VIII Method for producing high potency factor VIII

1978-12-04

1980-11-25

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, 2601125R, A61K 3514, A61K 3700

Patent

active

042358817

ABSTRACT:
Factor VIII preparations of enhanced potency are obtained from human blood donors by recovering blood from donors who have been treated with vasopressin analogs, such as 1-deamino-6-carba-8-D-arginine vasopressin, in an amount sufficient to increase the circulating blood level of Factor VIII in the donor.

REFERENCES:
patent: 3454549 (1969-07-01), Boissonnas
patent: 3497491 (1970-02-01), Zaoral et al.
patent: 3980631 (1976-09-01), Prochazka et al.
patent: 4157431 (1979-06-01), Fields et al.
Colin R., et al., Chemical Abstract, vol. 66, 84660p (1967).
Hershgold, E., et al., Chemical Abstracts, vol. 74 94474k (1971).
Cash, J., et al., Clinical Science and Molecular Medicine, 54, pp. 403-409 (1978).
Mannucci et al., The Lancet, 8017c, pp. 869-872 (1977).
Cort et al., Molecular Endocrinology, pp. 337-349, Holland Biomedical Press (1977).
Aberg, M., et al., Chemical Abstract, vol. 84, 41626m, 1976.

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