Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1987-10-13
1990-10-16
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 435 711, 4351723, 435255, 435256, 435320, 935 28, 935 37, 935 69, C12N 1500, C12N 500, C12P 2100, A61K 3900
Patent
active
049634836
ABSTRACT:
The hepatitis B virus preS2 antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae utilizing an optimized plasmid construction. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the high level expression of the preS2 as well as the S domain. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
REFERENCES:
patent: 4477571 (1984-10-01), Chang et al.
Bitter, et al. Gene 32:263-274, 1984.
Holland, et al. J. Biol. Chem 255:2596-2605, 1980.
Itoh, Y. Biochim, Biophip Res Comm 138(1): 268-274, 1986.
Valenzuela et al., EP Patent Application 0 174 444.
Budkowska, et al.; Ann. Inst. Past./Immuno. 136D:57-65 (1986).
Petit et al., Mol. Immun. 23:511-523 (1986).
Milich et al., PNAS 82:8168-8172 (1985).
Neurath et al., J. Med. Virol 17:119-125 (1985).
Neurath et al., Vaccine 4:34-37 (1986).
Itoh et al., PNAS USA 83:9174-9178 (1986).
Hilleman et al., Vaccine 4:75-76 (1986).
Scolnick et al., JAMA 251:2812-2815 (1984).
Valenzuela et al., Botechnology 3:317-320 and 292 (1985).
Ellis Ronald W.
Hagopian Arpi
Kniskern Peter J.
Montgomery Donna L.
Burrous Beth A.
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
Teskin Robin L.
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