Method for producing fumaric acid

Details Method for producing fumaric acid Method for producing fumaric acid

1996-03-28

1997-10-14

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435109, 435233, 435829, 435840, C12P 746, C12N 990

Patent

active

056771568

ABSTRACT:
Fumaric acid is produced by reacting maleic acid in an aqueous solution with a microorganism which has maleate isomerase activity or with a preparation from the microorganism having the maleate isomerase activity, and producing fumaric acid in a reaction solution by enzymatic isomerization of maleic acid carried out under the condition that the dissolved oxygen concentration in the reaction solution is substantially maintained at 4 ppm or less, for example, by sealing the reaction solution with one or more gases selected from N.sub.2, Ar, and He.

REFERENCES:
patent: 2332992 (1943-10-01), Davis
patent: 2816923 (1957-12-01), Stephenson
patent: 2955136 (1960-10-01), Sullivan et al.
patent: 4877731 (1989-10-01), Ling et al.
Ken'ichi Otsuka, "Isomerisation from Maleic Acid to Fumaric Acid", Agr. Biol. Chem., vol. 25, No. 9, pp. 726-730, 1961.

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