Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-08-03
2000-05-16
Carlson, Karen Cochrane
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1400
Patent
active
060639040
ABSTRACT:
A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.
REFERENCES:
patent: 5714314 (1998-02-01), Miyamura et al.
patent: 5734019 (1998-03-01), Miyamura et al.
patent: 5747241 (1998-05-01), Miyamura et al.
patent: 5750331 (1998-05-01), Miyamura et al.
Honda Yoshikazu
Matsuura Yoshiharu
Miyamura Tatsuo
Saito Izumu
Seki Makoto
Carlson Karen Cochrane
Japan as represented by the Director General of the Agency of Na
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