Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1998-01-09
1999-06-29
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435170, 4352523, 435280, 4353201, C12P 1322, C12P 4100
Patent
active
059167815
ABSTRACT:
The method for producing D-tryptophan with high optical purity and high yield is provided, which comprises contacting a mixture of D,L-tryptophan with organisms which produce tryptophanase to degrade L-tryptophan selectively, thereby increasing the content of D-tryptophan in D,L-tryptophan.
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Deeley et al., "Nucleotide Sequence of the Structural Gene for Tryptophanase of Escherichia coli K-12", J. of Bacteriol., 147:387-796, 1981.
Kawasaki et al., "Cloning and characterization of a tryptophanase gene from Enterobacter aerogenes SM-18", J. of General Microbiology, 139:3275-3281, 1993.
Kawasaki et al., "Enzymatic Synthesis of L-Tryptophan by Enterobacter aerogenes Tryptophanase Highly Expressed in Escherichia coli, and some Properties of the Purified Enzyme", Biosci. Biotech. Biochem, 59:1938-1943, 1995.
"Enzyme Nomenclature, 1992", Academic Press, Inc., 1992, p. 469.
Yoshida et al., "Purification, Crystallization and Properties of Tryptophanase from Proteus rettgeri", Arg. Biol. Chem., 38:2065-2072, 1974 .
Matsuyama Akinobu
Mitsuhashi Kazuya
Tomita Fusao
Yamamoto Hiroaki
Daicel Chemical Industries Ltd.
Lilling Herbert J.
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