Method for producing crystalline cefadroxil hemihydrate

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D50104, A61K 31545

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active

049047760

ABSTRACT:
The invention relates to a method for producing crystalline cefadroxil hemihydrate. According to the method a cefadroxil solvate is slurried with a mixture methanol:isopropyl alcohol 30:70 to 70:30 by volume containing from 5% to 12% of water, a temperature from +45.degree. C. to +55.degree. C. and then isolating the so obtained crystalline compound.

REFERENCES:
patent: 4504697 (1989-03-01), Bouzard
Pfeiffer et al., Jour. of Pharma. Sciences, vol. 59, No. 12, pp. 1810-1814 (1970).

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