Method for producing cryptophycins by cultivating a Nostoc sp.

Details Method for producing cryptophycins by cultivating a Nostoc sp. Method for producing cryptophycins by cultivating a Nostoc sp.

1996-11-04

1999-08-31

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435 711, 435120, 435128, 514183, 514478, C12P 2104, C12P 1304, C12P 1714, C12P 1300

Patent

active

059453150

ABSTRACT:
The present invention provides novel cryptophycin compounds having the following structure: ##STR1## The present invention also provides methods for producing cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.

REFERENCES:
patent: 4845085 (1989-07-01), Sesin
patent: 4845086 (1989-07-01), Sesin
patent: 4868208 (1989-09-01), Sesin et al.
patent: 4946835 (1990-08-01), Hirsch et al.
Spjut RW et al., Econ. Bot. 42(1):62-72 (1988).
Smith et al., "Cryptophycin: A New Antimicrotubule Agent Active Against Drug-Resistant Cells," Cancer Res. 54(14):3779-84 (1994).
Trimurtulu et al., "Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from the Blue-Green Alga Nostoc sp. Strain GSV 224," J. Am. Chem. Soc. 116(11):4729-37 (1994).
Schwartz et al., "Pharmaceuticals from Cultured ALgae," J. Ind. Microbiol. 5(2-3):113-23 (1990).

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