Method for producing coupling compound

Details Method for producing coupling compound Method for producing coupling compound

2007-05-15

2007-05-15

McKane, Joseph K. (Department: 1626)

Catalyst, solid sorbent, or support therefor: product or process

Catalyst or precursor therefor

Organic compound containing

C548S312400

Reexamination Certificate

active

10757148

ABSTRACT:
A method is provided for producing a specific crosscoupling compound and a specific catalyst for producing the compound. The method includes reacting in the presence of a base and a nickel compound catalyst organic halide of the formula n′(R1X1n), wherein R1is a hydrocarbon group and the α and β carbons to X′ are sp3carbon atoms; X1is a chlorine, bromine, or iodine atoms, and n and n1and 1 or 2 but not both 2, with a compound having the formula m{R2(BX22)n′} where an R2is an aryl, heteroaryl, or alkenyl group, and n′ is 1 or 2, X2is independently a hydroxyl group, an alkoxy or arylalkoxy group or X22together form an alkylenedioxy or arylenedioxy group, and m represents 1 or 2 but m≦n, and the boron atom is bonded to a sp2carbon atom of R2group or a boronic acid trimer anhydride.

REFERENCES:
patent: WO 01/66248 (2001-09-01), None
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Satake, “Synthesis of Neutral π-Allypalladium Complexes having Bisnitrogen Ligands and Palladium-Catalyzed Cyclopropanation of Ketene Silyl Acetals with Allylic Acetates”,Journal of Synthetic Organic Chemistry, vol. 58, No. 8, pp. 736-744, (2000).

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