Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1997-11-17
2000-10-03
Celsa, Bennett
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
435 4, 435 6, 435 71, 435DIG49, 436501, 436528, 436529, 436530, 436531, 436543, 530333, 530334, 536 185, 536 253, G01N 33531, G01N 33543
Patent
active
06127190&
ABSTRACT:
A technique is disclosed for generating nonrandom combinatorial libraries on solid phase supports in which each of a set of predetermined species of test compounds is present on a predetermined number of solid phase supports, preferably on only one, and each solid phase support has only a single species of test compound. Each of the predetermined species of test compounds is prepared with absolute certainty because the technique does not employ any random division of the solid phase supports. Rather, the method is based on the stepwise division of a continuous solid phase support matrix prior to each synthetic step in which more than one type of subunit is added. Non-limiting examples of matrices of the solid phase supports include polypropylene membranes, polytetrafluoropropylene membranes and cotton thread. The combinatorial libraries made by the technique are also disclosed.
REFERENCES:
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5556752 (1996-09-01), Lockhardt et al.
patent: 5688696 (1997-11-01), Lebl
Bray et al., 1993, Tetrahedron Letters, 34:4411-4414.
Campian et al., 1993, 13th APS Edmonton, Canada.
Daniels et al., 1989, Tetrahedron Letters 30:4345-4348.
Devlin et al., 1990, Science 249:404-406.
Eichler et al., 1991, Peptide Research 4:296-307.
Lebl and Eichler, 1989, Peptide Research 2:232-235.
McLafferty et al., 1993, Gene 128:29-36.
Merrifield, 1963, J. Am. Chem. Soc. 85:2149-2154.
Pinilla et al., 1993, Gene 128:71-76.
King et al., 1990, Int. J. Peptide Protein Res. 36: 255-266.
Krchnak and Vagner et al., 1988, Collect. Czech. Chem. Commun. 53:2541-2548.
Krchnak and Vagner, 1990, Peptide Research 3:182.
Lam et al., 1993, Bioorg. Med. Chem. Lett. 3: 419.
Lam et al., 1991, Nature 354:82.
Lam and Lebl, 1992, Immunomethods 1: 11-15.
Lebl et al., 1992, in C.h Schneider and A.N. Eberle, Eds.,Peptides: 67-69.
Moran et al. 1995, Angew. Chem. Int. Ed. Engl. 34: 2287-2291.
Nikolaiev et al., 1993, peptide Res. 6: 161-170.
Ohlmeyer et al., 1993, Proc. Natl. Acad. Sci. USA 90: 10922.
Pinill et al., 1992, Biotechniques 13:901.
Salmon et al., 1993, Proc. Natl. Acad. Sci. USA 90:11708.
Speth et al., 1989, Peptide Research 2: 232-237.
Stankova et al., 1994, Drug Development Research 33: 146-156.
Barrett et al., 1992, Anal. Biochem. 204: 357.
Bray et al., 1994, J. Organic Chem. 59: 2197.
Burgess et al., 1994, J. Med. Chem. 37: 2985.
Cwirla et al., 1990, Proc. Natl. Acad. Sci. USA 87: 6378-6382.
Eichler and Houghten, 1993, Biochemistry 32:11035.
Frank, 1993, Bioorganic and Medicinal Chemisty Letter 3:425.
Frank and Doring, 1988, Tetrahedron 44: 6031.
Frank, 1992, Tetrahedron 48: 9217.
Furka et al., 1991, Int. J. Peptide Protein Research 37: 487.
Furka et al., 1980, 14th International Congress of Biochemistry, Prague.
Furka, et al., 1988, X.sup.th International Symposium on Medicinal Chemistry, Budapest, 1988.
Gallop et al., 1994, J. Med. Chem. 37:1233.
Geysen et al., 1986, Molecular Immunology 23: 709.
Gordon et al., 1994, J Med Chem 37:1385.
Houghten et al., 1991, Nature 354: 84-86.
Jung and Beck-Sickinger, 1992, Angew Chem Int Ed Engl 31:367.
Kerr et al., 1993, J. Am. Chem. Soc. 115:2529.
Kerr et al., 1993, J. Am. Chem. Soc. 115:2529.
J. Eichler et al., Collect. Czech. Chem. Commun. 54: 1746-1752, 1989.
Needels, et al., "Generation and screening of an oligonucleotide-encoded synthetic peptide library", PNAS vol. 90, pp. 10700-10704 (1993).
Celsa Bennett
Ricigliano Joseph W.
Selectide Corporation
LandOfFree
Method for producing combinatorial libraries having a predetermi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for producing combinatorial libraries having a predetermi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing combinatorial libraries having a predetermi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-194430