Method for producing chiral α-hydroxycarboxylic...

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...

Reexamination Certificate

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C435S146000, C435S183000, C435S252100

Reexamination Certificate

active

07390647

ABSTRACT:
The invention relates to a method for producing chiral α-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into α-hydroxycarboxylic acids (R) or (S), respectively by enzymatic hydrolysis in the presence ofRhodococcus erythropolisNCIMB 11540.

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International Search Report for PCT/EP2004/000859 completed May 4, 2004, three pages.
Mei-Xiang Wang et al; “Enantioselective biotransformations of racemic a-substituted α-substituted phenylacetonitriles and phenylacetamides usingRhodococcussp. AJ270”; Tetrahedron: Asymmetry 11 (2000) 1123-35.
Ingrid Osprian et al; “Biocatalytic hydrolysis of cyanohydrins: an efficient approach to enantiopure α-hydroxy carboxylic acids”; Journal of Molecular Catalysis B: Enzymatic 24-25 (2003) 89-98; XP-002278959.

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