Method for producing cephem compounds

Details Method for producing cephem compounds Method for producing cephem compounds

1991-04-25

1992-11-10

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, 540215, 540221, C07D50104

Patent

active

051625229

ABSTRACT:
A method for producing 3-(3-oxobutyryloxymethyl)-3-cepham-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and in good yield, characterized by reacting a 3-hydroxylmethyl-3-cephem-4-carboxylic acid with diketene in the presence of a 4-(tertiary-amino)pyridine and if necessary, when a 7-acylamino-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid is obtained, subjecting it to deacylation at the 7-position thereof.

REFERENCES:
patent: 4323676 (1982-04-01), Tsushima et al.
patent: 4584371 (1986-04-01), Timko
patent: 4908444 (1990-03-01), Naito et al.
J. Org. Chem., 1984, vol. 49, No. 4, pp. 722-725.
R. J. Clemens, "Diketene," Chemical Reviews, vol. 86, No. 2, Apr. 1986, pp. 247-253, American Chemical Society, Washington, D.C., USA.

Affiliated with

Also associated with

Rating

Method for producing cephem compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing cephem compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing cephem compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2294979