Method for producing cephalexin

Details Method for producing cephalexin Method for producing cephalexin

2007-09-04

2007-09-04

Berch, Mark L. (Department: 1624)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

C540S230000

Reexamination Certificate

active

10501140

ABSTRACT:
The invention relates to a process for the preparation of cephalexin with the aid of a penicillin amidase immobilized on a crosslinked hydrophilic copolymer which has binding activity for ligands having nucleophilic groups and is in bead form.

REFERENCES:
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patent: 6060268 (2000-05-01), De Vroom
patent: 7011963 (2006-03-01), Meier et al.
patent: 19804518 (1999-08-01), None
patent: 97/04086 (1997-02-01), None
Travascio et al., Biotechnology and Bioengineering vol. 79, Issue 3, pp. 334-346 (Aug. 2002).
Travascio et al., Biotechnol. Prog., 18 (5), 975-985, (Jul. 2002).
L. Cao et al., Journal of Molecular Catalysis B: Enzymatic, vol. 11, Issues 4-6, Jan. 22, 2001, pp. 665-670.
Janssen Michiel H A et al: “Evaluation of the performance of immobilized penicillin G acylase using active-site titration” Biotechnology and Bioengineering, Bd. 78, Nr. 4, May 20, 2002, pp. 425-432, XP002274659 & ISSN: 0006-3592, the whole document.

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