Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1992-01-21
1995-09-26
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352401, 4352402, 4353201, 4352521, 4352523, 43525233, 4352528, 536 231, 536 235, 530350, C12P 2106, C07H 1700, C12N 500, C12N 1500
Patent
active
054533619
ABSTRACT:
The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.
REFERENCES:
patent: 4511502 (1985-04-01), Builder et al.
patent: 4620948 (1986-11-01), Builder et al.
patent: 4680262 (1987-07-01), Bochner et al.
patent: 4734362 (1988-03-01), Hung et al.
patent: 4758512 (1988-07-01), Goldberg et al.
patent: 4935370 (1990-06-01), Franke
patent: 4945046 (1990-07-01), Horii et al.
patent: 4961969 (1990-10-01), Hershenson et al.
Thanos et al., Eur. J. Neurosci. 1:19-26 (1989).
Kalcheim and Gendreau, Develop. Brain Res. 41:79-86 (1988).
Lindsay, J. Neurosci. 8:2394-2405 (1988).
Kalcheim et al., EMBO J. 6:2871-2873 (1987).
Davies et al., J. Neurosci. 6:1897-1904 (1986).
Johnson et al., J. Neurosci. 6:3031-3038 (1986).
Kalcheim & LeDouarin, Develop. Biol. 116:451-466 (1986).
Barde & Thoenen, in "Hormones and Cell Regulation", vol. 9, Dumont et al., eds., Elsevier Science Publishers, pp. 385-390 (1985).
Davies and Lindsay, Develop. Biol. 111:62-72 (1985).
Lindsay et al., J. Cell. Sci. Supp. 3:115-129 (1985).
Lindsay & Rohrer, Develop. Biol. 112:30-48 (1985).
Lindsay et al., Develop. Biol. 112:319-328 (1985).
Lindsay & Peters, Neurosci. 12:45-51 (1984).
Pearson et al., Develop. Biol. 96:32-36 (1983).
Sarthy et al., J. Neurosci. 3:2532-2544 (1983).
Turner et al., Dev. Brain Res. 6:77-83 (1983).
Lindsay et al., Brain Res. 243:329-343 (1982).
McCaffery et al., Exp. Brain Res. 48:377-386 (1982).
Barde et al., PNAS 77:1199-1203 (1980).
Johnson et al., Science 210:916-918 (1980).
Lindsay, Nature 282:80-82 (1979).
Barde et al., Nature 274:818 (1978).
Levi-Montalcini, The Harvey Lectures 60:217-259 (1966).
Rodriguez-Tebar and Barde, J., Neurosci. 8(9):3337-3342 (1988).
Barde et al., Prog. Brain Res. 71:185-189 (1987).
Davies et al., Nature 319:497-499 (1986).
Hofer et al., Nature 331:261-262 (1988).
Barde et al., Ann. Rev. Physiol. 45:601-612 (1983).
Barde et al., EMBO J. 1(5):549-553 (1982).
Lindsay and Tarbit, Neurosci. Lett. 12:195-200 (1979).
Walz et al., Biochem. Biophys. Res. Comm. 149:755-761 (1987).
Wion et al., FEBS Letters 203:82-86 (1986).
Jaenisch, Science 240:1468-1474 (1988).
Bruce, G., and G. Heinrich, 1989, Neurobiology of Aging 10:89-94.
Denefle, P., et al., 1989, Gene, 85:499-510.
Dicou, E., et al., 1989, Journal of Neuroscience Research, 22:13-19.
Evan, G. I., et al., 1985, Mol. Cell. Biol., 5:3610-16.
Fonnum, F., 1975, J. Neurochem., 24:407-409.
Goff, S. A., et al., 1984, Proc. Natl. Acad. Sci. USA, 81:6647-51.
Hallbook, F., et al., 1991, Neuron, 6:845-858.
Hedgpeth, J., et al., 1980, Proc. Natl. Acad. Sci. USA, 77:2621-2625.
Hohn, A., et al., 1990, Nature, 344:339-341.
Hu, G., et al., 1990, Abstracts: Soc. for Neuroscience, 20th Ann. Mtg., 16:343.16.
Hu, G., and K. E. Neet, 1988, Gene, 70:57-65.
Ibanez, C. F., et al., 1990, EMBO J., 9:1477-83.
Iwai, S., et al., 1986, Chem. Pharm. Bull., 34:4724-30.
Kaisho, Y., et al., 1990, FEBS Letters, 266:187-191.
Kanaya, E., et al., 1989, Gene, 83:65-74.
Kawaguchi, Y., et al., 1984, J. of Biotechnology, 1:307-315.
Leibrock, J., et al., 1989, Nature, 341:149-52.
Maisonpierre, P. C., et al., 1990, Science, 247:1446-51.
Marston, F. A. O., et al., 1984, Bio/Technology, Sep. 1984, pp. 800-804.
Meier, R., et al., 1986, EMBO J., 5:1489-1493.
Miller, K. W., et al., 1989, J. Bacteriol., 171(4):2166-72.
Obukowicz, M. G., et al., 1988, Mol. Gen. Genet., 215:19-25.
Panayotatos, N., 1987, "Engineering an Efficient Expression System," Plasmids--A Practical Approach, (Hardy, K., ed.), IRL Press, Oxford/Washington, D.C.
Rosenthal, A., et al., 1990, Neuron, 4:767-773.
Sambrook, J., et al., 1989, Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
Schwarz, M. A., et al., 1989, J. of Neurochemistry, 52:1203-1209.
Scott, J., et al., 1983, Nature, 302:538-540.
Selby, M. J., et al., 1987, J. of Neurosci. Res., 18:293-298.
Tsuji, T., et al., 1987, Biochemistry, 26:3129-34.
Twigg, A. J., and D. Sherratt, 1980, Nature, 283:216-18.
Ullrich, A., et al., 1983, Nature, 303:821-25.
Wong, E. Y., et al., 1988, Gene, 68:193-203.
Barde Yves-Alain
Leibrock Joachim
Lottspeich Friedrich
Thoenen Hans
Yancopoulos George
Hill Jr. Robert J.
Max Plank Gesselschaft zur Forderung der Wissenschaften
Regeneron Pharmaceuticals Inc.
Wang Gian P.
LandOfFree
Method for producing biologically active human brain derived neu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for producing biologically active human brain derived neu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing biologically active human brain derived neu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1551514