Method for producing asymmetric tetrasubstituted carbon...

Details Method for producing asymmetric tetrasubstituted carbon... Method for producing asymmetric tetrasubstituted carbon...

2011-04-19

2011-04-19

Chandrakumar, Nizal S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S015000, C548S408000, C562S506000

Reexamination Certificate

active

07928232

ABSTRACT:
The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent.The invention provides a method for producing a compound represented by formula (2):(wherein n is an integer of 2 to 5; R1represents a (substituted) alkyl group or a (substituted) aryl group; and R2represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1):(wherein n, R1, and R2are the same as defined above; and R3represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

REFERENCES:
patent: 5547962 (1996-08-01), Ito et al.
patent: 7563805 (2009-07-01), Takahashi et al.
patent: 2008/0300403 (2008-12-01), Nishimoto
patent: 3 95176 (1991-04-01), None
patent: 94 14794 (1994-07-01), None
patent: 7 224033 (1995-08-01), None
patent: 7 285934 (1995-10-01), None
patent: 7 309864 (1995-11-01), None
patent: 9 208561 (1997-08-01), None
Extended European Search Report issued Sep. 27, 2010, in Application No. 06746652.4-2101 / 1882685 PCT/JP2006309996.
Toshihiko Yoshida, et al., “Studies on Quinolone Antibacterials. V.1) Synthesis and Antibacterial Activity of Chiral 5-Amino-7-(-4-substituted-3-amino-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acid and Derivatives”, Chem. Pharm. Bull., vol. 44, No. 7, (Pharmaceutical Society of Japan, XP002942278, 1996, pp. 1376-1386.

Affiliated with

Also associated with

Rating

Method for producing asymmetric tetrasubstituted carbon... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing asymmetric tetrasubstituted carbon..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing asymmetric tetrasubstituted carbon... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2658171