Method for producing Aspartame derivative, method for...

Details Method for producing Aspartame derivative, method for... Method for producing Aspartame derivative, method for...

2005-09-06

2005-09-06

Zucker, Paul A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

06939987

ABSTRACT:
N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester is prepared by a process comprising:subjecting Aspartame and 3-(3-methoxy-4-hydroxyphenyl)propionaldehyde or derivatives thereof to reductive alkylation in a solvent to produce N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester; andcrystallizing said compound.

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S. Nishimura, “Handbook of Heterogeneous Catalytic Hydrogenation for Organic Synthesis”, John Wiley & Sons, NY, pp. 178-185, 2001.
T. Fukuda, “Nippon Kagaku Zasshi”, vol. 83, pp. 1126-1129, 1962.

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