Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis
Reexamination Certificate
2007-09-11
2007-09-11
Moran, Marjorie A. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Chemical analysis
C435S006120, C435S007100, C435S007800, C435S029000
Reexamination Certificate
active
10385558
ABSTRACT:
The present invention provides a method for identifying a member of a mass-coded combinatorial library which is a ligand for biomolecule and assessing the effect of the binding of the ligand to the biomolecule. The mass-coded molecular library comprises compounds of the general formula XYn, wherein n is an integer from 2 to about 6, X is a scaffold and each Y is, independently, a peripheral moiety. The mass-coded combinatorial library is produced by reacting a scaffold precursor with a sufficient number of distant peripheral moiety precursors such that there exist at least about 250 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors.
REFERENCES:
patent: WO 9701635 (1997-01-01), None
patent: WO 9701755 (1997-01-01), None
van Breeman et al. Pulsed ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Analytical Chemistry. (1997) vol. 69, pp. 2159-2164.
Carell et al. New promize in combinatorial chemistry: synthesis, characterization and screening of small-molecule libraries in solution. Chemistry and Biology. (1995) vol. 2, No. 3, pp. 171-183.
Hsieh et al. Multidimensional chromatography coupled with mass spectrometry for target-based screening. Molecualr Diversity (1996) vol. 2, pp. 189-196.
Birnbaum Seth
Jindal Satish
Kalghatgi Krishna
Nash Huw M.
Shipps Gerald
Kalyanaraman Palaiyur S.
Moran Marjorie A.
Schering Corporation
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