Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles
Patent
1993-03-29
1995-01-10
Pal, Asok
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitriles
558411, 560 8, C07C25500
Patent
active
053809106
ABSTRACT:
A method for producing an asymmetric biaryl derivative which comprises dehalogenocoupling halogenated benzene derivatives, wherein a bromobenzene derivative of the formula: ##STR1## wherein R is a lower alkyl group or a lower alkoxy group, which is attached at the 3- or 4-position, and a 2-chlorobenzene derivative of the formula: ##STR2## wherein R' is a cyano group or an alkoxycarbonyl group, are reacted in pyridine in the presence of triphenylphosphine, an anhydrous nickel compound and a reducing metal to obtain an asymmetric biaryl derivative of the formula: ##STR3## wherein R and R' are as defined above, and R is attached at the 3- or 4-position.
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patent: 4400566 (1983-08-01), Colon
patent: 4990647 (1991-02-01), Himmler et al.
Journal of Organic Chemistry, vol. 48, No. 25, Mar. 24, 1983, pp. 4904-4907, C. S. Chao, et al. "New Method For The Preparation Of Activated Nickel And Cobalt Powders And Their Application In Biaryl Synthesis".
Patent Abstracts of Japan, vol. 16, No. 194 (C-938), May 11, 1992, JP-A-40 29 957, Jan. 31, 1992.
Beilsteins Handbuch Der Organischen Chemie, 4th Edition, 3rd Supplement, vol. 9, part 4, 1971, pp. 3323-3324, Hans-G Boit.
Ihara Chemical Industry Co. Ltd.
Pal Asok
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