Method for producing an adapted virus population from an African

Details Method for producing an adapted virus population from an African Method for producing an adapted virus population from an African

1999-06-21

2000-09-12

McKelvey, Terry

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435239, C12N 700, C12N 702

Patent

active

061176672

ABSTRACT:
The invention described herein provides a method for selecting a novel African Green monkey kidney (AGMK) cell substrate, its cultivation and serial passage and its subsequent characterization. The invention provides a method for the use of the cell substrate in the isolation, growth and serial passage of a large number of viruses, particularly rotaviruses, enteroviruses, respiratory viruses and hepatitis A virus. The invention provides a method for the utilization of this AGMK cell substrate for the production of live and killed virus vaccines.

REFERENCES:
patent: 4783407 (1988-11-01), Provost et al.
Horaud, Biologicals, vol. 23: pp. 225-228, Sep. 1995.

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