Method for producing a rapidly dissolving dosage form

Details Method for producing a rapidly dissolving dosage form Method for producing a rapidly dissolving dosage form

1998-07-06

2000-05-23

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424465, 424466, 424489, 514774, A61K 914, A61K 916, A61K 946

Patent

active

060663375

ABSTRACT:
A particulate support matrix, and a dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into an aqueous environment. First, a porous particulate powder matrix which will serve as the dosage form matrix is produced. In a second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In a third step the mixture is formed into a dosage form. Finally, in a fourth step, a coating may be formed upon the outer surface of the dosage form to enhance the intactness and durability of the dosage form.

REFERENCES:
patent: 4013784 (1977-03-01), Speiser
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 5082667 (1992-01-01), Van Scoik
patent: 5178878 (1993-01-01), Wehling et al.
patent: 5215756 (1993-06-01), Gole et al.

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