Method for producing a posterior vitreous detachment

Details Method for producing a posterior vitreous detachment Method for producing a posterior vitreous detachment

1996-10-29

1998-03-03

Lacyk, John P.

Surgery

Miscellaneous

Methods

604 51, A61B 1900

Patent

active

057224285

ABSTRACT:
Methods for enzymatic production of a posterior vitreous detachment are provided. In preferred methods, dispase is used to cleave type IV collagen and fibronectin at the vitreoretinal junction to promote the posterior vitreous detachment. The methods provide for enzymatic treatment in conjunction with intraocular surgery as well as treatments to relieve the blinding complications of certain eye disorders without the need for surgery. Also disclosed are kits for production of a posterior vitreous detachment and devices containing the enzymes useful in the methods.

REFERENCES:
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patent: 5304118 (1994-04-01), Trese et al.
Webster's II New Riverside University Dictionary, 1994, (pp. 356, 1116).
O'Neill & Shea, Canad. J. Ophthalmol. 8:366-370, 1973.
Moorehead, et al., Arch. Ophthalmol. 98:1829-1839, 1980.
Verstraeten et al., Arch. Ophthalmol. 111:849-854, 1993.
Tezel, et al., ARVO Abstract, 1996.
Hesse, et al., Invest. Ophthalmol. Vis. Sci. vol. 36, ARVO Abstract No. 3492-479, 1995.

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