Method for producing a controlled-release preparation

Details Method for producing a controlled-release preparation Method for producing a controlled-release preparation

2005-12-13

2005-12-13

Spear, James M. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S474000, C424S475000, C424S479000, C424S480000, C424S482000, C424S468000, C514S772300, C514S777000, C514S781000

Reexamination Certificate

active

06974591

ABSTRACT:
The invention concerns a method for producing a controlled-release pharmaceutical preparation with a particle-containing coating, the coating being derived from an aqueous dispersion of a film-forming water insoluble polymer and a water soluble pore-forming agent. By suspending, instead of dissolving the pore-forming agent, the resulting coating will contain particles of the pore-formers with a predetermined size that creates, when disintegrated or dissolved in the body fluid, canals or a network of pores through the polymer film. Due to this network, the film will get a good mechanical stability and are left intact after the release of the drug.

REFERENCES:
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4629619 (1986-12-01), Lindahl et al.
patent: 5376383 (1994-12-01), Alberts et al.
patent: 5472712 (1995-12-01), Oshlack et al.
patent: 5639476 (1997-06-01), Oshlack et al.
patent: 6024982 (2000-02-01), Oshlack et al.

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