Method for producing a biocompatible layer on the surface of par

Details Method for producing a biocompatible layer on the surface of par Method for producing a biocompatible layer on the surface of par

1984-06-20

1987-01-06

Lovering, Richard D.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

210692, 210927, 424 33, 42721334, 42840222, 428407, B01J 1302

Patent

active

046346040

ABSTRACT:
The invention pertains to the method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents.
An object of the invention consists in the method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents by action of a solution of biocompatible polymer of acrylate or methacrylate type, or of its monomer in the presence of polymerization initiators, on a suspension of sorbent, which is agitated with steam.
The method according to the invention renders a material, the sorption capacity of which is entirely retained. This is due to water, which remains enclosed in the pores of sorbent and enables the sorption of toxins also inside the gel particles. In addition, steam can be prepared completely apyrogenic and thus to secure that the sorbents remain clean inside. Clinical tests reveal that the sorbents coated by the method according to the invention have an excellent hemocompatibility.

REFERENCES:
patent: 3576760 (1971-04-01), Gould et al.
patent: 3787522 (1974-01-01), Dickie et al.
patent: 4021364 (1977-05-01), Speiser et al.
patent: 4187194 (1980-02-01), Wellman et al.
patent: 4239646 (1980-12-01), Vincent et al.
patent: 4280923 (1981-07-01), Small et al.

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